Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Susceptibility background for type 2 diabetes in eleven Mexican Indigenous populations: HNF4A gene analysis. 28688048 2017
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Prolonged episodes of hypoglycaemia in HNF4A-MODY mutation carriers with IGT. Evidence of persistent hyperinsulinism into early adulthood. 27552834 2017
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 AlteredExpression disease BEFREE In obesity and type 2 diabetes, selective downregulation of Irs2 and its downstream actions to cause reduced insulin actions was associated with increased insulin actions through Irs1 in variety tissues. 28380373 2017
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 Biomarker disease BEFREE Half-Life of Sulfonylureas in HNF1A and HNF4A Human MODY Patients is not Prolonged as Suggested by the Mouse Hnf1a(-/-) Model. 26446475 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls. 26347889 2016
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 GeneticVariation disease BEFREE Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis. 26582067 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE The aim of the present study was to investigate the contribution of maturity-onset diabetes of the young (MODY) genes to the etiology of 14 Chinese MODY families and to assess phenotypic differences between patients with MODY but without a known genetic cause of diabetes (MODYX) and those with early onset type 2 diabetes (T2D). 25588466 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE This study, the first exploring the relation between HNF4A genetic variants and MetS and metabolic variables in a pediatric cohort, suggests that HNF4α could represent an early marker for the risk of developing type 2 diabetes mellitus. 25671620 2016
Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
0.900 GeneticVariation disease BEFREE Association of genetic variants in INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) with type 2 diabetes (T2D): a case-control study in three ethnic groups from North-West India. 26251103 2016
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 GeneticVariation disease BEFREE Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus. 27005817 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE The four polymorphisms, rs4810424, rs1884613, rs1884614 and rs2144908, in the HNF‑4α gene were not the susceptible loci for type 2 diabetes in the Bai population of Dali city, however, the haplotype, CCTA, built from the four SNPs may increase the risk of type 2 diabetes in this population. 26781905 2016
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 GeneticVariation disease BEFREE Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. 26290879 2016
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 Biomarker disease BEFREE Collectively, these findings indicate that cLDL, alone, attenuates glucose uptake via NO-mediated tyrosine nitration of IRS‑1 in L6 rat muscle cells and suggests the possibility that cLDL is involved in the pathogenesis of T2DM. 25779204 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Making the diagnosis of GCK-MODY through genetic testing is essential to avoid unnecessary treatment and investigations, especially when patients are misdiagnosed with type 1 or type 2 diabetes. 26106223 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes. 26315042 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE However, since HNF4A and KLF14 are established loci for type 2 diabetes, it is unlikely that HDL-C solely mediates these associations. 26670163 2016
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 GeneticVariation disease BEFREE Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5. 26868433 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes. 26981542 2016
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 GeneticVariation disease BEFREE Early-onset type 2 diabetes mellitus is associated to HNF4A T130I polymorphism in families of central Spain. 25361053 2015
Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
0.900 Biomarker disease BEFREE Genetic abnormalities in HNF4A and HNF1A lead to a dual phenotype of HH in the newborn period and maturity onset-diabetes later in life. 25733449 2015
Entrez Id: 5078
Gene Symbol: PAX4
PAX4
0.900 Biomarker disease BEFREE Overall, we did not find any evidence of susceptibility to ketosis associated with DRB1 and DQB1 genotypes (all P>0.05) in A(-) KPD compared to T2D. 25511714 2015
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.900 GeneticVariation disease BEFREE The AA (homozygous Arg972 IRS1) and GA (heterozygous Arg972 IRS1) genotypes were associated with an increased risk of AD after adjustment for comorbidities including type 2 diabetes mellitus, coronary heart disease, and hypertension (p<0.001; adjusted odds ratio [OR] 3.93 and 2.90, respectively). 24589556 2015
Entrez Id: 5078
Gene Symbol: PAX4
PAX4
0.900 GeneticVariation disease BEFREE Association of PAX4 genetic variants with oral antidiabetic drugs efficacy in Chinese type 2 diabetes patients. 24752311 2015