Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Less than 10 reports of adult-onset non-insulin-dependent diabetes mellitus (NIDDM) due to heterozygous NEUROD1 mutations and 2 cases with permanent neonatal diabetes mellitus (PNDM) and neurological abnormalities due to homozygous NEUROD1 mutations have been published. 29521454 2018
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE β Cell transcription factors such as forkhead box protein O1 (FoxO1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), pancreatic and duodenal homeobox 1, and neuronal differentiation 1, are dysfunctional in type 2 diabetes mellitus (T2DM). 28432716 2017
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. 26551672 2015
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Heterozygous loss-of-function mutations in NEUROD1 have previously been described as a cause of maturity-onset diabetes of the young (MODY) and late-onset diabetes. 25684977 2015
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Previous studies showed that a common A45T variant located in NEUROD1 was inconsistently associated with type 2 diabetes mellitus (T2DM) in different ethnic populations. 23203005 2013
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE The allelic frequency of NeuroD1/BETA2 T45 was higher in T2DM patients than in the control subjects [13.45 vs. 6.82%, P < 0.01, odds ratios = 2.342 (1.365, 4.019), P= 0.002]. 22296034 2012
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE In addition to these three major classes, we also review the available evidence on novel genes (CDK5 regulatory subunit associated protein 1-like 1 [CDKAL1], insulin-like growth factor 2 mRNA binding protein 2 [IGF2BP2], potassium voltage-gated channel, KQT-like subfamily, member 1 [KCNQ1], paired box 4 [PAX4] and neuronal differentiation 1 [NEUROD1] transcription factors, ataxia telangiectasia mutated [ATM], and serine racemase [SRR]) that have recently been proposed as possible modulators of therapeutic response in subjects with T2DM. 23018631 2012
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Our results suggest that 1) the NeuroD1-Ala45Thr variation may itself have an important role in susceptibility to or be in disequilibrium with early-onset T2DM in Chinese; 2) the Ala45Thr may affect the onset pattern of T2DM, i.e., early-onset but not late-onset T2DM in Chinese; and 3) onset-age stratified analysis may be useful to determine the association of NeuroD1-Ala45Thr variation with susceptibility to genetic heterogeneous T2DM in Chinese. 16773428 2006
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. 16873704 2006
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus. 16026366 2005
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Polymorphisms of these genes (Ala45Thr [NEUROD1], Ser199Phe [NEUROG3], and Ala98Val [TCF1]) have been postulated to influence the development of type 2 diabetes. 15277395 2004
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE The aims of the study were to determine the allele and genotype frequency of Ala45Thr polymorphism of BETA2/NeuroD1 in a Polish population and to examine the role of this amino acid variant in the genetic susceptibility to T2DM. 12861411 2003
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE It has recently been shown that mutations in BETA2/NeuroD1 are responsible for the development of type 2 diabetes mellitus (T2DM) in Caucasians. 12951629 2003
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE beta-Cell transcription factor genes are important in the pathophysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insulin promoter factor (IPF)-1, HNF-1beta, and NeuroD1/BETA2, all resulting in early-onset type 2 diabetes. 11272211 2001
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1. 11719843 2001
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. 11078465 2000
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE In conclusion, mutations in the NeuroD/BETA2 gene are not a common cause of late-onset type 2 diabetes among Danes. 10905500 2000
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. 10808064 2000
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 GeneticVariation disease BEFREE Because the variant of the NeuroD/BETA2 gene (Ala45Thr) is associated with type 1 but not type 2 diabetes, it may be implicated in the loss of pancreatic beta-cells in type 1 diabetes. 10334323 1999
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE There was no evidence of linkage with the markers for NEUROD1 and PAX4 either with MODY or late-onset Type II diabetes. 10230653 1999
Entrez Id: 4760
Gene Symbol: NEUROD1
NEUROD1
0.800 Biomarker disease BEFREE Our findings suggest that deficient binding of NEUROD1 or binding of a transcriptionally inactive NEUROD1 polypeptide to target promoters in pancreatic islets leads to the development of type 2 diabetes in humans. 10545951 1999