Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have become standards of care for diabetic nephropathy. 28177196 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE The combination of ARB and ACE inhibition is well tolerated and even more effective than monotherapy in reducing systemic blood pressure and albuminuria in diabetic nephropathy. 15017527 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression disease BEFREE Greater ACE activity was associated with DD genotype, and its role in diabetic nephropathy remains to be elucidated. 10352194 1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854 2013
Entrez Id: 213
Gene Symbol: ALB
ALB
0.600 Biomarker disease BEFREE Patients with DN (urinary albumin [UA] >30 mg/g of creatinine) whose estimated glomerular filtration rate (eGFR) was more than 30 mL/min were selected and their plasma renin, parathyroid hormone, serum Vitamin D, serum calcium, serum creatinine, fasting blood sugar were done as baseline measurements. 29386413 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.600 Biomarker disease BEFREE Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/ antioxidant response element (ARE) pathway, playing a significant role in inhibiting the fibrosis of diabetic nephropathy (DN). 29248720 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.600 Biomarker disease BEFREE Our present study suggested that Blnc1 can affect inflammation, oxidative stress and renal fibrosis by Nrf2/HO-1 and NF-κB pathways in DN. 31632538 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy. 12722028 2003
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE Although key signal transduction and gene regulation mechanisms have been identified, especially those related to the effects of hyperglycaemia, transforming growth factor β1 and angiotensin II, progress in functional genomics, high-throughput sequencing technology, epigenetics and systems biology approaches have greatly expanded our knowledge and uncovered new molecular mechanisms and factors involved in DN. 25003613 2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.600 AlteredExpression disease BEFREE The beneficial effects of zinc on DN are achieved most likely due to the upregulation of Nrf2 and its downstream factors NQO1, SOD1, SOD2. 28595780 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.600 Biomarker disease BEFREE To investigate this hypothesis, db/db diabetic mice were used to establish a DKD model and the PPARγ agonist rosiglitazone was employed to induce PGC‑1α expression in vivo. 29344670 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.600 Biomarker disease BEFREE The ASO also reduced expression of genes involved in matrix expansion such as fibronectin and collagen (I and IV) and an inhibitor of matrix degradation, PAI-1, in the renal cortex, contributing to significant reversal of mesangial expansion in both models of DN. 17554073 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression disease BEFREE Moreover, APPA reduced the levels of transforming growth factor-β1, collagen IV, and laminin in HBZY-1cells incubated in high glucose, and in serum in DN rats. 28802633 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The D allele of the angiotensin-converting enzyme (ACE) gene has been linked with diabetic nephropathy and IgA glomerulonephritis and with faster renal disease progression. 10821348 2000
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 AlteredExpression disease BEFREE Ad-SOCS2 infection alleviated STZ-induced renal injury and pathological changes and inhibited STZ-induced IL-6, IL-1β and MCP-1 generation and activation of the TLR4/NF-κB pathway in DN rats. 29207635 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.600 Biomarker disease BEFREE The Impact of Peroxisome Proliferator-Activated Receptor Gamma and Its Interaction with Abdominal Obesity on Diabetic Nephropathy in Chinese Han. 28013303 2017
Entrez Id: 213
Gene Symbol: ALB
ALB
0.600 Biomarker disease BEFREE Diabetic nephropathy (DN) as a cause, CKD stages, body mass index (BMI), smoking, leukocyte count, serum albumin, iron markers, calcium, and phosphorus concentration were identified as independent risk factors for anemia. 28049235 2017
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.600 GeneticVariation disease BEFREE Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy. 25280384 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker disease BEFREE Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy via modulation of the TGF-β1/Smad/miR-192 signaling pathway. 31572545 2019
Entrez Id: 213
Gene Symbol: ALB
ALB
0.600 Biomarker disease BEFREE The observation suggests that changes in transglomerular albumin traffic are demonstrable prior to the onset of diabetes and diabetic nephropathy in subjects with a potential genetic predisposition to these conditions. 9150479 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy: a methodologic appraisal and systematic review. 9727374 1998
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Suppression of AGEs induced TGF-beta1, CTGF and Fn mRNA overexpression in renal fibroblasts through inhibition of oxidative stress may be a mechanism underlying effect of ginkgo biloba extract in diabetic nephropathy. 17531120 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression disease BEFREE Intraglomerular TGF-beta 1 mRNA was elevated, even in the early stage of diabetic nephropathy. 8691733 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN. 26619914 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The frequency of ACE DD genotype in patients with diabetic nephropathy was significantly higher than in patients without nephropathy (22.3 vs 13.4%, P<0.05). 10862639 2000