Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE Our results demonstrate that HG-induced cholesterol accumulation and cellular injury in podocytes may be related to the recycling disorder of ABCA1 caused by the downexpression of Arf6 in DKD. 31206670 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE Furthermore, our group has recently shown that ATP-binding cassette A1 (a protein involved in cholesterol and phospholipid efflux) is significantly reduced in clinical and experimental DKD and that genetic or pharmacological induction of ABCA1 is sufficient to protect from DKD. 31754839 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE We demonstrated that this pathway is relevant to DKD and that ABCA1 inducers or inhibitors of cardiolipin peroxidation may each represent therapeutic strategies for the treatment of established DKD. 31329164 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE Fourth, clinical and experimental evidence support a role for ATP-binding cassette sub-family A member 1-dependent cholesterol efflux, free fatty acids and glycerophospolipids in the pathogenesis of diabetic kidney disease. 24861084 2014
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE We report a cellular defect in ABCA1-mediated cholesterol efflux in monocytes from CKD patients with diabetic nephropathy. 28478047 2017
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.060 Biomarker disease BEFREE In this study we investigated the effect of exendin-4 on ABCA1 in glomerular endothelial cells of diabetic kidney disease (DKD) and the possible mechanism. 27784780 2016
Entrez Id: 85320
Gene Symbol: ABCC11
ABCC11
0.020 AlteredExpression disease BEFREE Gene expression of MRP8 and Tlr4 is further upregulated during worsening of STZ-induced DN by a high fat diet (HFD). 24357461 2014
Entrez Id: 85320
Gene Symbol: ABCC11
ABCC11
0.020 Biomarker disease BEFREE Among all subjects, by univariate linear regression analysis, glomerular MRP8-positive cell count and tubulointerstitial MRP8-positive area at baseline were both, respectively, correlated not only with various known risk factors for diabetic nephropathy (such as systolic blood pressure, proteinuria and serum creatinine) but also with extent of glomerulosclerosis and tubulointerstitial fibrosis. 24558454 2014
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.010 Biomarker disease BEFREE All these results indicated that MLP-1 can effectively inhibit renal fibrosis and potentially treat DN. 30521918 2019
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.020 AlteredExpression disease BEFREE Gene expression of MRP8 and Tlr4 is further upregulated during worsening of STZ-induced DN by a high fat diet (HFD). 24357461 2014
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.020 Biomarker disease BEFREE Among all subjects, by univariate linear regression analysis, glomerular MRP8-positive cell count and tubulointerstitial MRP8-positive area at baseline were both, respectively, correlated not only with various known risk factors for diabetic nephropathy (such as systolic blood pressure, proteinuria and serum creatinine) but also with extent of glomerulosclerosis and tubulointerstitial fibrosis. 24558454 2014
Entrez Id: 32
Gene Symbol: ACACB
ACACB
0.040 Biomarker disease BEFREE Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy. 24650564 2014
Entrez Id: 32
Gene Symbol: ACACB
ACACB
0.040 GeneticVariation disease BEFREE We have identified the acetyl-coenzyme A carboxylase beta gene (ACACB) as a strong susceptibility gene to diabetic nephropathy in individuals with type 2 diabetes. 20514549 2010
Entrez Id: 32
Gene Symbol: ACACB
ACACB
0.040 GeneticVariation disease BEFREE To date, case-control studies on the association between a single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene and diabetic nephropathy have provided controversial results. 26030797 2015
Entrez Id: 32
Gene Symbol: ACACB
ACACB
0.040 Biomarker disease BEFREE To investigate the biological roles of ACCβ in the pathogenesis of diabetic nephropathy, we examined the effects of overexpression of ACACB using podocyte-specific ACACB-transgenic mice or ACACB-overexpressing murine podocytes. 29175208 2018
Entrez Id: 84680
Gene Symbol: ACCS
ACCS
0.010 AlteredExpression disease BEFREE Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPARα, CPT-1). 31585912 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have become standards of care for diabetic nephropathy. 28177196 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE The combination of ARB and ACE inhibition is well tolerated and even more effective than monotherapy in reducing systemic blood pressure and albuminuria in diabetic nephropathy. 15017527 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression disease BEFREE Greater ACE activity was associated with DD genotype, and its role in diabetic nephropathy remains to be elucidated. 10352194 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE It is suggested that the ACE gene DD genotype might be a significant risk factor for the progression of diabetic nephropathy. 12722028 2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The D allele of the angiotensin-converting enzyme (ACE) gene has been linked with diabetic nephropathy and IgA glomerulonephritis and with faster renal disease progression. 10821348 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy: a methodologic appraisal and systematic review. 9727374 1998
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN. 26619914 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The frequency of ACE DD genotype in patients with diabetic nephropathy was significantly higher than in patients without nephropathy (22.3 vs 13.4%, P<0.05). 10862639 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Meta-analysis of the relationship between ACE I/D gene polymorphism and end-stage renal disease in patients with diabetic nephropathy. 22385293 2012