Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 GeneticVariation disease BEFREE Here, we studied the potential effect of TXNIP on podocyte phenotypic alterations in diabetic nephropathy (DN) in vivo and in vitro. 30746698 2019
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE Modulating the FOXO1/TXNIP-TRX pathway may be a new therapeutic target in DN. 30962862 2019
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 AlteredExpression disease BEFREE The data revealed that TXNIP and NLRP3 were overexpressed in kidney tissue of DN rats, and the level of antioxidant genes was downregulated. 31017263 2019
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE Thioredoxin-interacting protein (TXNIP) plays an important role in the development of diabetic nephropathy. 30142540 2018
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE Thioredoxin-interacting protein (TXNIP) is associated with inflammation, tubulointerstitial fibrosis, and oxidative stress in diabetic kidney disease, yet the potential role of TXNIP in nondiabetic renal injury is not well known. 29884908 2018
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE Medicinal plants possess various bioactive constituents, which may slow or ameliorate the progression of DN and improve renal function through the targeting of multiple pathological causes via different pathways, including p38MAPK, JNK, ERK, TGF-β, RhoA, NF-κB, Wnt, JAK-STAT, AMPK, mTOR, Akt, and TXNIP. 29433676 2018
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE Since thioredoxin-interacting protein (TXNIP) has been shown to play an important role in the pathogenesis of diabetic kidney disease, we tested whether glucose could induce expression of TXNIP in the kidney by epigenetic mechanisms. 26806835 2016
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 AlteredExpression disease BEFREE TXNIP and TXN are upregulated in urinary sediment of T1D patients with diabetic kidney disease (DKD), but only TXNIP expression is associated with magnitude of eGFR decline. 26480949 2016
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 AlteredExpression disease BEFREE TXNIP is associated with activation of oxidative stress and tubulointerstitial fibrosis in diabetic nephropathy. 24492284 2014
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 AlteredExpression disease BEFREE We demonstrated recently that thioredoxin-interacting protein (Txnip) and the transcription factor Krüppel-like factor 6 (KLF6) were up-regulated in both in vivo and in vitro models of diabetic nephropathy, thus promoting renal injury. 19808645 2009
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease CTD_human In the present study, the relationship between diabetic nephropathy and Txnip was investigated using streptozotocin (STZ)-induced diabetic mice. 17582205 2007
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.400 Biomarker disease BEFREE VDUP-1 mediates collagen accumulation in mesangial cells and could be the molecular mediator/marker for fibrosis in diabetic nephropathy caused by chronic hyperglycemia such as diabetes. 14531794 2003