Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE Progressive reduction of SnoN is associated with gradual elevation of TGF-β1 during diabetic nephropathy progression, suggesting SnoN to be a possible mediator of TGF-β1 signaling, with potential therapeutic benefits against TGF- β1 -induced renal fibrosis. 28350874 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE To identify the role of KCa3.1 in dysfunctional tubular autophagy in diabetic nephropathy, human proximal tubular cells (HK2) transfected with scrambled or KCa3.1 siRNAs were exposed to TGF-β1 for 48 h, then autophagosome formation, the autophagy marker LC3, signaling molecules PI3K, Akt and mTOR, and oxidative stress marker nitrotyrosine were examined respectively. 27029904 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker disease BEFREE MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy. 28277542 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker disease CTD_human Thus, in line with the role of PPARγ in metabolic homeostasis, Pparg null-mice first represent a potent model for studying the initiation and the development of diabetic nephropathy. 28182703 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.400 GeneticVariation disease BEFREE Association of fibronectin Msp iv polymorphism and diabetic nephropathy susceptibility in Chinese Han population. 26045844 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN. 26619914 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker disease BEFREE To determine the role of SK1 and S1P in inducing fibrosis and inflammation, and the interaction with TGFβ-1, 2 and 3 signalling in diabetic nephropathy, human proximal tubular cells (HK2 cells) were exposed to normal (5 mmol/L) or high (30 mmol/L) glucose or TGFβ-1, -2, -3 ± an SK inhibitor (SKI-II) or SK1 siRNA. 26414003 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Carrying the D-allele of the angiotensin-converting enzyme (ACE) I/D polymorphism and high ACE activity are prognostic factors in diabetic nephropathy, which predicts mortality in type 1 diabetes. 23833037 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE Transforming growth factor-beta1 (TGF-β1), a ubiquitously expressed pro-fibrotic cytokine plays a pivotal role in mediating the hypertrophic and fibrotic manifestations of DN. 25871499 2016
Entrez Id: 213
Gene Symbol: ALB
ALB
0.400 Biomarker disease BEFREE Increased urinary albumin excretion rate is the earliest clinical manifestation of diabetic nephropathy. 27036319 2016
Entrez Id: 213
Gene Symbol: ALB
ALB
0.400 Biomarker disease BEFREE Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. 26631737 2016
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE The results revealed that variations of ACE and eNOS gene had association with DN, which indicated ACE and eNOS gene may play an important role in pathogenesis of DN in Northern Chinese Han population. 25227524 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy. 25227524 2016
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.400 Biomarker disease BEFREE Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN. 26619914 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE The renoprotective and antifibrosis effects of β2GPI and reduced β2GPI on DN were closely associated with suppressing the activation of the TGF-β1-p38 MAPK pathway. 26045739 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE The effects of some RAAS gene variants, including angiotensin converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (AT1R), on the risk for DN have been studied more extensively, but there has been controversy. 26619914 2016
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 AlteredExpression disease BEFREE We assessed MBL levels and corresponding MBL2 genotype, together with vascular endothelial growth factor (VEGF) levels as a marker of vascular damage, in type 1 diabetes patients with diabetic nephropathy before and after simultaneous pancreas-kidney (SPK) transplantation. 26768002 2016
Entrez Id: 9844
Gene Symbol: ELMO1
ELMO1
0.400 AlteredExpression disease BEFREE High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. 26858454 2016
Entrez Id: 84735
Gene Symbol: CNDP1
CNDP1
0.400 Biomarker disease BEFREE Carnosinase 1 (CN1) contributes to diabetic nephropathy by cleaving histidine-dipeptides which scavenge reactive oxygen and carbonyl species and increase nitric oxide (NO) production. 26081982 2016
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.400 Biomarker disease BEFREE Urinary mRNA levels of CXCL10 and CXCL11 are decreased, and those of collagen I A1 chain and fibronectin are increased in diabetic nephropathy. 25865428 2016
Entrez Id: 84735
Gene Symbol: CNDP1
CNDP1
0.400 GeneticVariation disease BEFREE Homozygosity for a 5-leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been associated with a reduced prevalence of diabetic nephropathy in cross-sectional studies in patients with type 2 diabetes, particularly in women. 24756973 2016
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 GeneticVariation disease BEFREE Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy. 25280384 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. 25791940 2015
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.400 AlteredExpression disease BEFREE Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. 25791940 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression disease BEFREE miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. 24887517 2015