Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE This review addresses this novel scenario, presenting data indicating that S100B levels and/or distribution in the nervous tissue of patients and/or experimental models of different neural disorders, for which the protein is used as a biomarker, are directly related to the progress of the disease: acute brain injury (ischemic/hemorrhagic stroke, traumatic injury), neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis), congenital/perinatal disorders (Down syndrome, spinocerebellar ataxia-1), psychiatric disorders (schizophrenia, mood disorders), inflammatory bowel disease. 30144068 2019
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE The discovery of neuroinflammatory changes, including dramatic proliferation of activated glia overexpressing a chromosome 2 gene product--the pluripotent immune cytokine interleukin-1 (IL-1)--and a chromosome 21 gene product--S100B--in the brains of fetuses, neonates, and children with DS opened the possibility that early events in Alzheimer pathogenesis were driven by cytokines. 23866266 2013
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE HSA21 associated S100B and amyloid precursor protein (APP) levels are simultaneously increased within DS HNPs, their secretions are synergistically enhanced in a paracrine fashion, and overexpressions of these proteins disrupt mitochondrial membrane potentials and redox states. 21779383 2011
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease LHGDN We further demonstrate in DS NPCs that S100B is constitutively overexpressed, that overexpression leads to increased reactive oxygen species (ROS) formation and activation of stress response kinases, and that activation of this pathway results in compensatory AQP4 expression. 17984171 2008
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE We further demonstrate in DS NPCs that S100B is constitutively overexpressed, that overexpression leads to increased reactive oxygen species (ROS) formation and activation of stress response kinases, and that activation of this pathway results in compensatory AQP4 expression. 17984171 2008
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE The relative levels of D21S167 and S100B were 2.1 and 2.7 times higher in the amniotic fluid of Down syndrome fetuses than those in the control group. 15861490 2005
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease LHGDN The higher levels of S100B in DS patients may reflect a general and persistent increase in the extracellular space and may be associated with neurodegenerative lesions observed in DS patients. 15820773 2005
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE In humans, the gene for S100B is found on chromosome 21, within what is considered the obligate region for Down Syndrome (DS) and levels of S100B are increased in brain of both DS and Alzheimer's Disease (AD). 15126113 2004
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE S100B overexpression correlates with Alzheimer pathology in post-adolescent Down syndrome patients and has been implicated in Abeta plaque pathogenesis. 15290893 2004
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE S-100 beta, a gene triplicated in Down Syndrome (DS), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. 12742260 2003
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease CTD_human Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome. 12888777 2003
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE Elevated levels of S100-beta have been observed reliably in the brains of patients with Alzheimer's Disease and Down Syndrome. 11222062 2001
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE In this regard, beta amyloid precursor protein (APP), CuZn superoxide dismutase (SOD1) and S100beta have been implicated in causing apoptosis, a mechanism thought to be responsible for neuronal loss in DS, in one way or another. 11858695 2001
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE Such precocious astrocyte activation and S100beta overexpression are similar to our earlier findings in Down's syndrome. 10617132 2000
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 GeneticVariation disease BEFREE This study was devised to evaluate and compare the methods for detecting trisomy 21 by polymerase chain reaction (PCR)-associated analysis of small tandem repeats (STR) of D21S11 and semiquantitative analysis of S100B of chromosome 21. 9933820 1999
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE A combined alteration such as up-regulation of S100beta together with down-regulation of Bcl-2 may be important in the pathogenesis of Alzheimer's disease and Down's syndrome. 10381557 1999
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE S-100 b protein, the gene for which maps to the long arm of chromosome 21, (a) is overproduced in DS patients, (b) produces growth inhibition and differentiation of neural cells in vitro, (c) is abundant in good-prognosis neuroblastomas, and (d) has been shown to induce growth inhibition and differentiation and cell death in several human and murine neuroblastoma cell lines and could be responsible for this variation. 9458088 1998
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE S-100 beta is increased in the postmortem brains of both DS and Alzheimer's disease. 9439795 1997
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE These results demonstrate an increase in S100 beta mRNA and protein levels during infancy indicative of postnatal astrocytic maturation and show that there is no gross deregulation in the expression of the S100 beta gene in DS as a consequence of trisomy 21. 8965656 1996
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE It is postulated that S-100 b protein may inhibit the development of neuroblastomas in Down's syndrome either antenatally, or after birth and may be a therapeutic agent against neuroblastoma. 8733171 1996
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE In Alzheimer's disease and Down's syndrome, severely afflicted brain regions exhibit up to 20-fold higher levels of S100 beta protein, and astrocytes surrounding neuritic plaques exhibit highly elevated levels of S100 beta immunostaining. 8750867 1995
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE S100 beta levels are elevated in Down syndrome (DS), and the gene for S100 beta is located on chromosome 21, which is duplicated in DS. 8192834 1994
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 AlteredExpression disease BEFREE These results indicate that gene-dosage effect of S-100 beta levels are expressed in DS patients. 2150320 1990
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS. 2146955 1990
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.400 Biomarker disease BEFREE Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. 2964086 1988