Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway. 26077125 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. 25007187 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. 21064136 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Methotrexate-induced myelopathy responsive to substitution of multiple folate metabolites. 19821069 2010
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. 19159907 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. 19391036 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. 17387702 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. 18551038 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice. 17502830 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. 16166815 2005
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.300 Biomarker group CTD_human MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. 15753437 2005