Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 Biomarker disease BEFREE Aromatase may be an excellent diagnostic test for endometriosis. 30965114 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression. 31527378 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Our data identify differentially expressed proteins S100A9 and S100A8, and suggest they may serve as novel molecular markers to predict postoperative recurrence of an ovarian endometriotic cysts.<b>Abbreviations:</b> iTRAQ: isobaric tags for relative and absolute quantitation; HPRD: Human Protein Reference Database; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; EM: Endometriosis; COX-2: cyclooxyenase-2; NF-kB: nuclear factor kappa-B; PR-B: progesterone receptor type B. 31714804 2020
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Dienogest, a specific progesterone receptor agonist, is used in the treatment of endometriosis. 31814016 2020
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 Biomarker disease BEFREE Management of recurrent implantation failure by gonadotropin-releasing hormone agonist and aromatase inhibitor suppression, in women without evidence of endometriosis. 30328740 2019
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 AlteredExpression disease BEFREE Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up-regulation is one of main mechanism involved. 31199588 2019
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 Biomarker disease BEFREE As an attractive approach for the treatment of endometriosis-associated pelvic pain, IVRs delivering a combination of the aromatase inhibitor anastrozole (ATZ) and the progestin levonorgestrel (LNG) have been developed. 31174438 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Patients with endometriosis presented lower levels of progesterone receptor type B expression. 30638056 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.600 GeneticVariation disease BEFREE Driver mutations in PIK3CA, KRAS, ARID1A, and other genes have been found in the epithelium of intrauterine endometrial tissue, ovarian and extraovarian pelvic endometriosis tissue, ovarian cancers associated with endometriosis (i.e., clear cell and endometrioid type), and other epithelial ovarian cancers. 30657901 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE These findings suggest that inflammation and MAPKs pathways respond for the abnormal expression of COX-2, which can elucidate the pathophysiology of endometriosis. 30773096 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.600 GeneticVariation disease BEFREE A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. 31185482 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.600 Biomarker disease BEFREE Taken together, these results show that IL-10 secreted from local plasmacytoid dendritic cells promotes endometriosis development through pathological angiogenesis during the early disease stage. 31418859 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 GeneticVariation disease BEFREE The <i>PGR-A</i> gene showed 0% of DNA methylation (unmethylated) in both control and endometriosis groups. 30782101 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Btk inhibitor Ibrutinib prevented lesion growth, reduced mRNA expression of cyclooxygenase-2, alpha smooth muscle actin and type I collagen in the lesions and skewed activated B cells toward Bregs in the spleen and peritoneal cavity of mice with endometriosis. 31247078 2019
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 AlteredExpression disease BEFREE Moreover, treatment of endometriosis xenografts with GW4064 suppressed aromatase and ERβ expression in nude mice. 30428773 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.600 AlteredExpression disease BEFREE M-MDSCs from EM PBMCs inhibited proliferation and activity in autologous T cells. rhCCL25 promoted IL-10 and GM-CSF secretion and arginase enzymatic activity in CD33<sup>+</sup> CD14<sup>+</sup> CD11b<sup>+</sup> HLA-DR<sup>-</sup> M-MDSCs. 30375700 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.600 Biomarker disease CTD_human Elevated serum chemokines are independently associated with both endometriosis and uranium exposure. 30579999 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.600 AlteredExpression disease BEFREE The serum and peritoneal fluid levels of IL-1β and IL-10 were not statistically significantly different between the endometriosis and control groups. 30632819 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE The prevalence and immunohistologic study (Ki-67, BAF250a, COX-2) of cases of cellular and architectural atypia in endometriosis were analyzed. 31074246 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.600 Biomarker disease BEFREE Compared to endometriosis group, IFNγ, IL-7, and IL-15 were observed to be significantly higher in the PF of the control group, and IL-10 was lower in the control group (p < 0.05). 30712043 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Additionally, endometriotic stromal cells (ESCs; n = 3) from ectopic endometriosis lesions were cultured and incubated with/without NGF and/or Trk inhibitor K252a, followed by expression analysis of prostaglandin-endoperoxide synthase 2 (PTGS-2)/cyclooxygenase 2 (COX-2; reverse transcription quantitative real-time polymerase chain reaction and Western blot) and prostaglandin E2 (PGE2) secretion (enzyme-linked immunosorbent assay). 28673205 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE An immunohistochemistry study demonstrated that the estrogen receptor (ER) and progesterone receptor (PR) were positive in the endometriosis part but negative in the cancer part, while the human EGF receptor (HER) 2 was negative or very weak in the benign part and positive in the malignant part in all three cases. 29998468 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice. 29615065 2018
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 Biomarker disease BEFREE A total of 420 women with colorectal endometriosis treated with combined oral contraceptives, progestins, gonadotropin releasing-hormone (GnRH) agonists and aromatase inhibitors have been described in eight case series, two retrospective cohort studies and four case reports. 29431849 2018
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
0.600 Biomarker disease BEFREE Two key pathways have been implicated: while there is contradictory data on the participation of the aromatase enzyme (encoded by <i>CYP19A1</i>), there is increasing evidence that the steroid sulphatase pathway plays a role in both the aetiology and pathology of endometriosis. 30030390 2018