Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10565
Gene Symbol: ARFGEF1
ARFGEF1
0.010 Biomarker disease BEFREE ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. 31678406 2020
Entrez Id: 1797
Gene Symbol: DXO
DXO
0.010 Biomarker disease BEFREE Also observed, T allele of IL-1β-31 and IL1-RAI/I were substantially positively correlated with drug resistance against those who responded well to antiepileptic drugs (AEDs).<b>Conclusions:</b> The significant association with IL-1β-31T and IL1-RAN*I alleles potentiated their useful role as predictive markers for the development of epilepsy and response to medical therapy. 31698971 2020
Entrez Id: 3098
Gene Symbol: HK1
HK1
0.010 AlteredExpression disease BEFREE The gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) plays several significant roles in cellular processes, including ATP synthesis, reactive oxygen species formation, and the regulation of glycolytic enzyme activity, which are closely related to the pathophysiological mechanisms of epilepsy. 31790668 2020
Entrez Id: 5901
Gene Symbol: RAN
RAN
0.010 GeneticVariation disease BEFREE Also observed, T allele of IL-1β-31 and IL1-RAI/I were substantially positively correlated with drug resistance against those who responded well to antiepileptic drugs (AEDs).<b>Conclusions:</b> The significant association with IL-1β-31T and IL1-RAN*I alleles potentiated their useful role as predictive markers for the development of epilepsy and response to medical therapy. 31698971 2020
Entrez Id: 729230
Gene Symbol: CCR2
CCR2
0.010 Biomarker disease BEFREE In the present study, the effects of CCR2 antagonist was investigated using the pilocarpine rat model of epilepsy. 31785482 2020
Entrez Id: 51079
Gene Symbol: NDUFA13
NDUFA13
0.010 AlteredExpression disease BEFREE The gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) plays several significant roles in cellular processes, including ATP synthesis, reactive oxygen species formation, and the regulation of glycolytic enzyme activity, which are closely related to the pathophysiological mechanisms of epilepsy. 31790668 2020
Entrez Id: 10743
Gene Symbol: RAI1
RAI1
0.010 Biomarker disease BEFREE Also observed, T allele of IL-1β-31 and IL1-RAI/I were substantially positively correlated with drug resistance against those who responded well to antiepileptic drugs (AEDs).<b>Conclusions:</b> The significant association with IL-1β-31T and IL1-RAN*I alleles potentiated their useful role as predictive markers for the development of epilepsy and response to medical therapy. 31698971 2020
Entrez Id: 6487
Gene Symbol: ST3GAL3
ST3GAL3
0.010 GeneticVariation disease BEFREE A novel non-sense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9. 31584066 2020
Entrez Id: 11130
Gene Symbol: ZWINT
ZWINT
0.010 Biomarker disease BEFREE Generic quality of life was the same in patients with poststroke epilepsy and patients with stroke only, however, the SA-SIP-30 showed a lower disease-specific quality of life in patients with poststroke epilepsy. 31477536 2020
Entrez Id: 10059
Gene Symbol: DNM1L
DNM1L
0.010 Biomarker disease BEFREE One of these pathogenic de-novo mutations, in DNM1L, was previously reported in a patient with severe epilepsy and chronic pharmacoresistance adding to the evidence for DNM1L as an epilepsy gene. 30711678 2020
Entrez Id: 51062
Gene Symbol: ATL1
ATL1
0.010 Biomarker disease BEFREE These findings suggest that atlastin-1 likely contributes to the occurrence and development of epilepsy through inhibitory synaptic transmission. 31729196 2020
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.010 Biomarker disease BEFREE The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca<sup>2+</sup>-permeable cation channel that contributes to cell apoptosis; its possible signaling pathway is the PARP1/BNIP3/AIF/Endo G pathway that may be related to epilepsy. 31794795 2020
Entrez Id: 84504
Gene Symbol: NKX6-2
NKX6-2
0.010 AlteredExpression disease BEFREE The phenotypic and neuroimaging expression in NKX6-2 is described and it is shown that phenotypes with epilepsy in the absence of overt hypomyelination and diffuse hypomyelination without seizures can occur. 31509304 2020
Entrez Id: 2919
Gene Symbol: CXCL1
CXCL1
0.010 Biomarker disease BEFREE Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis. 31699822 2020
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
0.010 Biomarker disease BEFREE These results suggest a key role of the phagocyte NADPH oxidase NOX2 and MPO in epilepsy and identify a novel effect of ketamine. 31667656 2020
Entrez Id: 54498
Gene Symbol: SMOX
SMOX
0.010 AlteredExpression disease BEFREE In this study, we analysed the effect of spermine oxidase over-expression in a different epileptic model, pentylenetetrazole. 31197571 2020
Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
0.010 Biomarker disease BEFREE The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca<sup>2+</sup>-permeable cation channel that contributes to cell apoptosis; its possible signaling pathway is the PARP1/BNIP3/AIF/Endo G pathway that may be related to epilepsy. 31794795 2020
Entrez Id: 8482
Gene Symbol: SEMA7A
SEMA7A
0.010 AlteredExpression disease BEFREE Second, to explore the role of Sema7A in the regulation of seizure activity, we conducted epilepsy-related behavioral experiments after knockdown and overexpression of Sema7A in the rat hippocampal dentate gyrus (DG). 31179640 2020
Entrez Id: 9131
Gene Symbol: AIFM1
AIFM1
0.010 Biomarker disease BEFREE The transient receptor potential melastatin type 2 channel (TRPM2) is a Ca<sup>2+</sup>-permeable cation channel that contributes to cell apoptosis; its possible signaling pathway is the PARP1/BNIP3/AIF/Endo G pathway that may be related to epilepsy. 31794795 2020
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.010 Biomarker disease BEFREE These results suggest a key role of the phagocyte NADPH oxidase NOX2 and MPO in epilepsy and identify a novel effect of ketamine. 31667656 2020
Entrez Id: 493901
Gene Symbol: RNASE12
RNASE12
0.010 Biomarker disease BEFREE Also observed, T allele of IL-1β-31 and IL1-RAI/I were substantially positively correlated with drug resistance against those who responded well to antiepileptic drugs (AEDs).<b>Conclusions:</b> The significant association with IL-1β-31T and IL1-RAN*I alleles potentiated their useful role as predictive markers for the development of epilepsy and response to medical therapy. 31698971 2020
Entrez Id: 10580
Gene Symbol: SORBS1
SORBS1
0.010 Biomarker disease BEFREE The present study also highlighted the fact that STAMBP mutation‑associated MIC‑CAP often presents as intractable early‑life epilepsy, which may lead to mortality. 31638258 2019
Entrez Id: 151393
Gene Symbol: RMDN2
RMDN2
0.010 Biomarker disease BEFREE Tau protein is a microtubule-associated protein (MAP) that has been implicated in the pathophysiology of both epilepsy and AD. 31532186 2019
Entrez Id: 860
Gene Symbol: RUNX2
RUNX2
0.010 Biomarker disease BEFREE The prevalence of CCD is one in a million of live births, and epileptic seizures are rarer in this disease. 30961565 2019
Entrez Id: 4987
Gene Symbol: OPRL1
OPRL1
0.010 AlteredExpression disease BEFREE Our results demonstrated a novel cellular and molecular mechanism whereby activation of ORL-1 receptors depresses epilepsy. 30998945 2019