Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Further, for NF-κB p65, MDR1, P-gp and apoptosis-associated protein levels detection, miR-542-3p mimic showed a suppressive effect on these KA-induced protein levels, whereas TLR4 overexpression ameliorated the miR-542-3p-induced these protein levels in KA-treated epilepsy rats. 31702493 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Our data provide key signaling steps underlying seizure-induced P-gp up-regulation and suggest that mPGES-1 inhibitors could potentially prevent P-gp up-regulation in epilepsy.-Soldner, E. L. B., Hartz, A. M. S., Akanuma, S.-I., Pekcec, A., Doods, H., Kryscio, R. J., Hosoya, K.-I., Bauer, B. Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier. 31638830 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Neuroinflammation due to high levels of glutamate has been identified as one of the causes of P-gp upregulation, and several studies in animal models of epilepsy suggest that antiinflammatory drugs might prevent P-gp overexpression and, thus, avoid the development of refractory epilepsy. 31420290 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Our data support the hypothesis that glutamate signals cPLA2 activation, resulting in overexpression of blood-brain barrier P-gp and BCRP.-Hartz, A. M. S., Rempe, R. G., Soldner, E. L. B., Pekcec, A., Schlichtiger, J., Kryscio, R., Bauer, B. Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy. 31661303 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Increasing evidence supports that the efflux transporters, especially P-glycoprotein (P-gp), have vital roles on drug resistance in epilepsy. 31061316 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Indeed, many genes, including genes encoding drug transporters (ABCB1), drug targets (SCN1A), drug-metabolizing enzymes (CYP2C9, CYP2C19), and human leucocyte antigen (HLA) proteins, may regulate the mechanisms of drug resistance in epilepsy. 29804481 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE Association between ABCB1 polymorphisms and response to first-generation antiepileptic drugs in a Tunisian epileptic population. 29198163 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE This study investigates the effect of the Pgp inhibitor verapamil on the anticonvulsant effect of CBZ and its nanoparticulate formulation in the rat model of isoniazid-induced epilepsy. 29751140 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE This study aimed to assess whether [<sup>11</sup>C]flumazenil is a P-glycoprotein substrate in humans and to what extent increased P-glycoprotein function in epilepsy may confound interpretation of clinical [<sup>11</sup>C]flumazenil studies used to assess gamma-aminobutyric acid A receptors. 26661244 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE The genetic polymorphism of ABCB1 rs1045642 was found to be associated with normalized OXC concentration and therapeutic efficacy in patients with epilepsy (P<0.05). 28837897 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Therapeutic disease RGD By compared to the epilepsy model group, the P-gp expression was not markedly attenuated by the inhibition of NF-κB activity with PDTC treatment, nevertheless with a decrease of NF-κB expression in this intervention group. 28303499 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 Biomarker disease BEFREE Hence, our findings support the combination of flavonoid-type P-gp inhibitors and P-gp substrate antiepileptic drugs as a potential therapeutic strategy for the management of pharmacoresistant epilepsy. 28602600 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE Exposing isolated rat brain capillaries to glutamate ex vivo upregulated P-gp expression to levels that were similar to those in capillaries isolated from rats that had status epilepticus or chronic epilepsy. 28195743 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE The expression levels of P-gp and its encoded gene mdr1a/b were significantly up-regulated on the brain of KA-induced chronic epilepsy rats or the epilepsy rats treated with CBZ for 1 week, meanwhile with a high expression of PXR. 28303499 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis. 28202008 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. 26122019 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE C3435T polymorphism of MDR1 gene was analysed by the high resolution melting technique in a group of patients with drug-resistant (n = 106) and drug-responsive epilepsy (n = 67), as well as in non-epileptic children (n = 98) hospitalised at the Department of Neurology, Polish Mother's Memorial Hospital in Lodz. 27391700 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 AlteredExpression disease BEFREE The present study attempted to evaluate association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and P-gp activity with treatment response in patients with epilepsy. 25121365 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE In this case-control study, we have investigated the role of ABCB1 rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 single nucleotide polymorphisms in antiepileptic drug-resistance in patients with epilepsy. 27886333 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE The association between the non-synonymous polymorphism G2677T/A in the coding region of the ABCB1 gene, and the risk of resistance to anti-epileptic drugs (AEDs) in epilepsy remains controversial. 26220385 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects. 25799371 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE Previous studies reported the associations between the ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with risk of response to antiepileptic drugs in epilepsy, however, the results were inconclusive. 25816099 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB. 26421491 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE The ABCB1 3435C>T polymorphism and type of epilepsy were associated with response to PB. 25846690 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.600 GeneticVariation disease BEFREE These findings rule out the MDR1 c.3435C>T polymorphism having a major role or increasing the risk of drug-resistance suggesting a revision is required to determine the contribution of this polymorphism in predicting drug response in epilepsy. 25458099 2015