Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 Biomarker disease BEFREE Several studies on factors associated with genetic susceptibility to spinal osteophyte formation, such as VDR and TGF-beta1. 17515815 2007
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 GeneticVariation disease BEFREE When the genotype data were used to construct haplotypes, the VDR AaTt joint genotype appeared to pose a remarkably lower odds (OR = 0.26, 95% CI = 0.08-0.91) of osteophyte compared with the AAtt joint genotype. 16507122 2006
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 GeneticVariation disease BEFREE The B allele of the VDR gene was associated with increasing severity of osteophyte. 15801025 2005
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 Biomarker disease BEFREE The strongest associations observed (statistically significant after correcting for multiple comparisons) were between COX2 and change in osteophyte grade (P < 0.001) and Kellgren-Lawrence grade (P < 2 x 10(-5)), and between the genes for vitamin D receptor (P < 0.002) and a thrombospondin (THSD2) (P < 0.002) and change in osteophyte grade. 16261124 2005
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 GeneticVariation disease BEFREE We had previously found the VDR genotype to be associated with osteophytes and the K/L score, but not with JSN. 10902746 2000
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 GeneticVariation disease BEFREE Allelic variation in the vitamin D receptor gene was associated with severity of osteophytosis (adjusted OR "TT" v "tt" 0.41, 95% CI 0.17, 0.97), presence of disc narrowing (adjusted OR "TT" v "tt" 0.45, 95% CI 0.20, 0.99) and weakly with presence of osteophytosis (adjusted OR "TT" v "tt" 0.47, 95% CI 0.19, 1.16) but not with severity of disc narrowing (OR "TT" v "tt" 1.05, 95% CI 0.40, 2.72) or apophyseal arthritis (OR "TT" v "tt" 0.63, 95% CI 0.24, 1.59). 9613338 1998
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 Biomarker disease BEFREE Our results indicate a role of the VDR gene in the pathogenesis of osteophytes while linkage disequilibrium with another nearby gene, i.e., the collagen type IIa1 gene encoding the most abundant protein in cartilage, might contribute to the association. 9218501 1997