Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 AlteredExpression disease BEFREE Liver hepatocellular cells (HepG2) were treated with high concentration of glucose to be subsequently used for the assessment of miR-141 and SIRT1 levels in a model of hepatic steatosis. 31256424 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Resveratrol, a sirtuin 1 (SIRT1) agonist, prevents ER stress and improves ER stress-induced hepatic steatosis and cell death. 31183612 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner. 31842467 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE To model human fatty livers, we repopulated decellularized rat livers with human mesenchymal cells, fibroblasts, macrophages, and human SIRT1 knockdown iPSC-derived hepatocytes and found that the human iPSC-derived liver tissue developed macrosteatosis, acquired proinflammatory phenotype, and shared a similar lipid and metabolic profiling to human fatty livers. 31390551 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy. 31105592 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 AlteredExpression disease BEFREE Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression. 30232347 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Activating AMPK<i>α</i> negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK<i>α</i> through mediating SIRT1 to suppress the development of fatty liver. 29681936 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Several in vitro and in vivo studies have shown the known protective effects of SIRT1 activators, such as resveratrol and SRT1720, on diabetes- or obesity-induced fatty liver and insulin resistance. 29402742 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway. 29595075 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway. 30214535 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE The present study demonstrated that SIRT1 activation attenuated HFD‑induced liver steatosis and inflammation by inhibiting CD36 expression and the NF‑κB signaling pathway. 29845302 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE The results revealed that the SIRT1/AMPK pathway is involved in the functions of the three flavonones, and the most effective flavonone against hepatic steatosis might be PCBG, followed by MPG and PCB. 30154382 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE In comparison with placebo, GC significantly increased Sirt1 and decreased hs-CRP, TNF-α, IL-6, ALT, and the degree of fatty liver (<i>P</i> < 0.05). 30263038 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE In vivo studies showed that hepatitis C virus core protein 1b-induced hepatic steatosis was attenuated in liver-specific Sirt1 KO mice by downregulation of PPARγ2 expression. 28898508 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 AlteredExpression disease BEFREE Mice administered 0.02% scopolin for 8 weeks exhibited improved phenotypes of HFD-induced hepatic steatosis along with increased hepatic SIRT1 activity and protein expression. 28533555 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. 28667519 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 GeneticVariation disease BEFREE Adenovirus-mediated liver-specific expression of SIRT1 or a phosphor-defective S164A-SIRT1 mutant promoted fatty acid oxidation and ameliorated liver steatosis and glucose intolerance in diet-induced obese mice, but these beneficial effects were not observed in mice expressing a phosphor-mimic S164D-SIRT1 mutant. 28533219 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, controlling hepatic oxidative stress and mediating hepatic inflammation through deacetylating some transcriptional regulators against the progression of fatty liver diseases. 28808418 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.(Hepatology 2017;66:809-824). 28439947 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Massive studies have suggested that liver steatosis is closely associated with the inhibition of silent information regulator 1 (SIRT1) and the augment of lipin1 β/α ratio mediated by ethanol. 28467182 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE We are the first to demonstrate that the SIRT1/HMGB1 pathway is a key therapeutic target for controlling NAFLD inflammation and that SalB confers protection against HFD- and PA-induced hepatic steatosis and inflammation through SIRT1-mediated HMGB1 deacetylation. 26525891 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE APS treatment suppressed abnormal glycolipid metabolism and insulin resistance following 8 weeks of catch‑up growth by improving hepatic SIRT1‑PPARα‑FGF21 intracellular signaling and reducing chronic inflammation, and by partially attenuating hepatic steatosis. 26323321 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Therapeutic disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014