Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE Collectively, the results of the present study revealed a new mechanism underlying the regulation of hepatic ER stress and FGF21 expression induced by EPO; thus, EPO may be considered as a potential therapeutic agent for the treatment of fatty liver and obesity. 31173165 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. 31668386 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE <b>Results:</b> FGF-21 levels were significantly higher in subjects with high-grade liver steatosis (<i>P</i> < 0.001). 31750276 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE This study aimed to evaluate FGF-21 as a biomarker for severe hepatic steatosis in non-obese HIV-infected patients. 30916873 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE The significant positive correlation of FGF-21 with ALT, gamma glutamyltransferase (GGT), triglycerides, homeostatic model assessment-insulin resistance (HOMA-IR), the degree of liver steatosis in ultrasound and TILC in <sup>1</sup>H-MRS were found. 30921653 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE This study assessed pegbelfermin (BMS-986036), recombinant PEGylated human fibroblast growth factor 21 (FGF21), in patients with obesity and T2DM predisposed to fatty liver. 30520566 2019
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE In NASH mice, administration of PsTag600-FGF21 reduced hepatic steatosis, fibrosis and inflammation. 29870802 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE With consumption of HFHS diet, FGF21 deficient mice (FGF21 KO) develop excess fatty liver within 16 weeks. 29753678 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Concentration of FGF-21 was greater in fatty liver cows, while the concentration of LP-PLA2 and Hb was less. 30206404 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE PsTag600-FGF21 dose-dependently reduced body weight, blood glucose, and insulin and lipid levels and reversed hepatic steatosis. 29859019 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Constitutive ISR activation in the liver induces FGF21 and confers protection from HFD-induced adiposity, IR, and HS in mice. 29698569 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Berberine attenuated hepatic steatosis and controlled energy balance in mice by inducing autophagy and FGF21. 29065221 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Moreover, by using a neutralizing antibody against FGF21, Fgf21-null mice and by treating mice with recombinant FGF21, we show that FGF21 may protect against hepatic steatosis by attenuating endoplasmic reticulum (ER) stress-induced VLDLR upregulation. 29289645 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Here, we show that chronic PD retards the development of hypertrigylceridemia and fatty liver in obesity and that this relies on the induction of the hepatokine fibroblast growth factor 21 (FGF21). 29751292 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE Their body weight, glucose-lipid metabolism, inflammation indices, hepatic steatosis and fibroblast growth factor 21 (FGF21) levels were measured. 30355361 2018
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE These results suggest that FGF21 can be used for early identification of hepatic steatosis. 28698650 2017
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE ACC DKI mice had improved glucose and insulin tolerance and a reduction in body weight, body fat and hepatic steatosis similar to WT mice in response to FGF21 administration. 28580278 2017
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE Chronic treatment with recombinant FGF21 reduces serum and hepatic triglyceride levels and ameliorates fatty liver in obese mice, through the suppression of the lipogenic gene, Srebp-1. 28337713 2017
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE Fatty liver and FGF21 physiology. 28549912 2017
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE Importantly, estrogen replacement restored hepatic FGF21 levels and reduced hepatic steatosis in HFFD-fed OVX rats. 28559436 2017
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE FGF21 depletion exacerbated alcohol-induced hepatic steatosis and liver injury, which was associated with increased activation of genes involved in lipogenesis mediated by SREBP1c and decreased expression of genes involved in fatty acid β-oxidation mediated by PGC1α. rhFGF21 administration reduced alcohol-induced hepatic steatosis and inflammation in WT mice. 27498701 2016
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 AlteredExpression disease BEFREE Forced FGF21 expression in partial hepatectomized hPPARα(PAC) reduced hepatic steatosis, prevented focal necrosis, and restored liver mass. 25991671 2015
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE APS treatment suppressed abnormal glycolipid metabolism and insulin resistance following 8 weeks of catch‑up growth by improving hepatic SIRT1‑PPARα‑FGF21 intracellular signaling and reducing chronic inflammation, and by partially attenuating hepatic steatosis. 26323321 2015
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE The administration of FGF21 reverses hepatic steatosis, counteracts obesity and alleviates insulin resistance in rodents and nonhuman primates. 25516477 2015
Entrez Id: 26291
Gene Symbol: FGF21
FGF21
0.400 Biomarker disease BEFREE FGF21 KO mice were subjected to chronic-binge alcohol exposure, and epididymal white adipose tissue lipolysis and liver steatosis were investigated. 26092866 2015