Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE We observed here that NGF and its pro-form, pro-NGF, are elevated in fatty livers from leptin-deficient mice compared with controls, concomitant with an increase in low density lipoprotein receptors (LDLRs). 26984409 2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2016
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease MGD Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. 25621497 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl. 23651953 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. 24525044 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin. 23024365 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Our findings indicate a significant relationship of hepatic fibrosis and hepatic steatosis with IR and leptin levels, but not with the viral load in Turkish patients with CHC. 23114743 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE In logistic regression analysis, only insulin resistance was associated with portal inflammation), lobular inflammation and steatosis; liver steatosis was related with leptin levels, too. 22530350 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE We found LCOR expression decreased in fatty livers of leptin-deficient (ob/ob) mice, diet-induced obese mice, as well as patients, suggesting LCOR may play a role in lipid homeostasis. 21827732 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Adoptive transfer of iNKT cells into obese mice or in vivo activation of iNKT cells via their lipid ligand, alpha-galactocylceramide, decreased body fat, triglyceride levels, leptin, and fatty liver and improved insulin sensitivity through anti-inflammatory cytokine production by adipose-derived iNKT cells. 22981538 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 GeneticVariation disease BEFREE Homozygous Leptin(145E/145E) mutant mice exhibited morbid obesity, accompanied by adipose hypertrophy, energy imbalance, and liver steatosis. 21151569 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE These changes were also accompanied by altered serum levels of leptin, adiponectin, and insulin, as well as by prevention of steatosis (fatty liver) in ActRIIB-mFc-treated ORX mice. 20573726 2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease LHGDN Mean serum leptin level and body mass index in the non-alcoholic fatty liver disease (NAFLD) group were significantly higher than in the controls, but mean soluble leptin receptor level was lower in the NAFLD group when compared to the controls. 18473416 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease LHGDN Findings show a preventive effect of leptin against progressive liver injury in non-alcoholic fatty liver disease. 18753993 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Along with downregulation of BDNF to approximately 30% of wild-type animals, Timo/Timo mice exhibited increased body weight and fat content with hepatic steatosis and elevated serum levels of leptin, cholesterol, and LDL cholesterol. 17652166 2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human It has been suggested that leptin, which has a relationship with body fat stores, may be involved in the pathogenesis of hepatic steatosis. 12661780 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human In this study, we compared serum leptin levels in tamoxifen-treated patients with and without hepatic steatosis. 12661780 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Serum leptin levels were found to be significantly elevated in patients with increased hepatic steatosis (37.3 +/- 17.7 to 50.5 +/- 22.4 ng/ml, p = 0.023) compared to (48.2 +/- 20.2 to 42.6 +/- 14.9 ng/ml, p > 0.05) after tamoxifen treatment. 12661780 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Serum leptin levels are associated with tamoxifen-induced hepatic steatosis. 12661780 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Leptin may play a role in tamoxifen-induced hepatic steatosis. 12661780 2003