Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 AlteredExpression disease BEFREE Intestinal permeability, hepatic steatosis and mRNA and protein expressions of TLR4-related inflammatory signaling molecule were analyzed. 31788011 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease BEFREE We found that selective hepatocyte TLR4 deletion protected mice from chronic alcohol-induced liver injury and fatty liver. 29884546 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease BEFREE Genetic and pharmacological suppression of the LPS-TLR4 pathway or transplantation with Tlr4<sup>-/-</sup> bone-marrow-derived hematopoietic cells increases beige fat development and ameliorates diet-induced fatty liver, while Tlr4<sup>-/-</sup> or microbiota-depleted mice are resistant to further CR-stimulated metabolic alterations. 30174308 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease BEFREE Hepatic steatosis was decreased 32-fold in the absence of TLR4. 28351520 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 AlteredExpression disease BEFREE Methionine-choline-deficient mice given 5% fructo-oligosaccharides exhibited significantly decreased hepatic steatosis (p = 0.003), decreased liver inflammation (p = 0.005), a decreased proportion of CD14-positive Kupffer cells (p = 0.01), decreased expression of TLR4 (p = 0.04), and increases in fecal short-chain fatty acid and IgA concentrations (p < 0.04) compared with the findings in methionine-choline-deficient mice that were not administered this prebiotic. 28632732 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease CTD_human Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. 27022031 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease BEFREE All of these findings demonstrated that BA or BT might ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro, promising agents for ethanol-induced fatty liver therapies. 23816536 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 GeneticVariation disease BEFREE Recent reports have suggested that PNPLA3, IL28B and TLR4-associated single nucleotide polymorphisms (SNPs) may have an impact on hepatic steatosis or fibrosis in patients with chronic HCV infection. 24349054 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 AlteredExpression disease BEFREE We have shown that mice deficient in IRF3 or TLR4 expression are protected from alcohol-induced liver steatosis, inflammation and hepatocyte injury. 23075869 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.380 Biomarker disease CTD_human Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. 18641190 2008