Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells. 30208561 2018
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma. 29653579 2018
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells. 28849227 2017
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 PosttranslationalModification disease BEFREE YWHAG was able to accelerate the phosphorylation of MDM4 and lead to the degradation of P53, which provides a potential mechanism for the tumor-promoting role of miR-217 in glioblastoma cells. 28126486 2017
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE Human CD9 (TSPAN29/MRP-1), a close homolog of tsp2A, was found to be expressed in glioma cell lines A172 and U343MG as well as in the majority of glioblastoma samples (16/22, 73 %). 26224160 2015
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE MDM4 and USP2a, as well as the MDM4-USP2a complex, were more highly expressed in glioblastoma multiforme tissue samples from patients with good prognosis compared with patients with poor prognosis. 24445145 2014
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE We identify an increased expression of the multiple drug resistance-associated protein 1 (Mrp1) in glioblastoma multiforme biopsies and in T98G and G44 cell lines. 21544552 2011
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease CTD_human HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 20472715 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE In conclusion, after Etoposide intervention glioblastoma stem-like cells showed a stronger resistance to apoptosis and death, and the anti-apoptotic gene livinbeta was more related with the high survival rate and MRP1 appeared to be more related with transporting chemotherapeutics out of glioblastoma stem-like cells. 20388502 2010
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE Univariate analysis of collected data demonstrated that the expressions of O(6)-MGMT and MRP-1 detected by immunohistochemistry, in addition to the consistent factors, including preoperative Karnofsky performance scale (KPS), radical surgery, and tumor location and extension, were significant prognostic factors for the overall survival (OS) of patients with glioblastoma, who received nimustine (ACNU)-based chemotherapy in association with surgery and radiotherapy. 19019175 2009
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE The properties of glioblastoma and astrocytoma stem-like cells on anti-apoptotic and MRP genes are: anti-apoptotic gene livin and survivin are elevated in CSCs but are the most increased in just differentiated CSCs; MRP1 gene is significantly increased and MRP3 is decreased in CSCs, but when differentiating the MRP3 gene starts a remarkable increase in CSCs; the expression of anti-apoptotic and MRP genes shows no differences between the CSCs isolated from glioblastoma and astrocytoma tissues. 18462887 2008
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE We have studied gene amplification of genes located in 1q32 (GAC1, ELF3, MDM4, and ren1), 4q11 (PDGFR-alpha), and in 12q13-14 (MDM2 and CDK4) using quantitative real-time PCR in a group of 86 tumors consisting of 44 WHO grade IV glioblastomas (GBM) (34 primary and 10 secondary tumors), 21 WHO grade III anaplastic astrocytomas (AA), and 21 WHO grade II astrocytomas (AII). 16319692 2005
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE Brain vessels extracted from tissue sections of nonmalignant human brain and glioblastoma tumors by laser capture microdissection microscopy and analyzed by real-time polymerase chain reaction showed higher expression of ABCG2 relative to ABCB1/MDR1 and ABCC1/MRP1. 12958161 2003
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE We found that a considerable expression of P-gp was relatively rare in glioma cells, in contrast to MRP1, which was constitutively overexpressed in cells derived from astrocytomas as well as glioblastomas. 12125964 2002
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 AlteredExpression disease BEFREE Furthermore, our results that exhibit protein expression of MRP1 and MRP3 and gene expression of MRP4 and MRP5 in these 2 glioblastoma cell lines suggest new mechanisms that could lead to a MDR phenotype of tumour cells in patients with glioblastoma multiforme. 11857404 2002
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.400 Biomarker disease BEFREE We investigated a series of 208 gliomas (106 glioblastomas, 46 anaplastic gliomas, and 56 low-grade gliomas) and identified 5 tumors (4 glioblastomas and 1 anaplastic oligodendroglioma) with MDM4 amplification and overexpression. 10626796 1999