Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Our findings reveal novel pathogenic mechanisms driven by ATRX deficiency in glioma, while also pointing to tangible strategies for drug development. 30808951 2019
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE One hundred seventy six cases of glioma were assessed for ATRX immunohistochemistry and subdivided into positive, negative and mosaic/heterogeneous staining patterns. 26833422 2017
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma. 29545335 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE However, CDKN loss, ATRX mutation and coexisting gain of chromosome 7/loss of chromosome 10 showed no clinical significance in this glioma entity. 30298540 2019
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE In adults, ATRX aberrations were detected in 33 % of grade II and 46 % of grade III gliomas, as well as in 80 % of secondary and 7 % of primary GBMs. 22886134 2012
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma. 23104868 2012
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. 30226859 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE ATRX in lower-grade gliomas could be predicted using radiomic analysis. 29404769 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE In the current study, we performed ATRX-IHC in 78 gliomas whose ATRX statuses were comprehensively determined by whole exome sequencing. 29550880 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. 26936505 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE The results indicate immunohistochemical analysis including IDH1/2, ATRX, p53, and Ki-67 index is valuable for the classification of diffuse gliomas, which is useful for the evaluation of prognosis, especially Grade III gliomas and lower-grade gliomas (i.e., Grade II and III). 26968173 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE The presence of ATRX mutations in glioma serves as a marker of better prognosis with longer patient survival although the underlying mechanisms are poorly understood. 29378238 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Our results showed ATRX-related regulatory functions of the combined profiles from DNA methylation and mRNA expression in astrocytic tumors, and delineated that loss of ATRX impacted biological behaviors of astrocytic tumor cells, providing important resources for future dissection of ATRX role in glioma. 25971279 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE AZD1775 also selectively inhibited the proliferation of patient-derived primary cell lines from gliomas with naturally occurring ATRX mutations, indicating that the synthetic lethal relationship between WEE1 and ATRX could be exploited in a broader spectrum of human tumors. 31551363 2020
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. 24559763 2014
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE p-Hsp27 is a novel biomarker of glioma and might have important clinical value for further classification of patients with wild-type IDH1 and normal ATRX expression, for evaluating prognosis and for guidance for adjuvant therapy. 29550762 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X-linked (ATRX) genes have been the subject of numerous studies on the classification and prognosis of glioma. 30655743 2019
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease CTD_human The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. 24705251 2014
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the most common type of primary malignant brain tumors. 22869205 2012
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Subsequent subgroup analysis largely confirms many of the currently used molecular classification schemes for diffuse gliomas (ATRX or TP53 mutations, 1p19q codeletion). 26699864 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE The Role of ATRX in Glioma Biology. 29034211 2017
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Translation of these findings to patients with IDH1<sup>132H</sup> glioma harboring TP53 and ATRX loss could improve the therapeutic efficacy of radiotherapy and, consequently, patient survival. 30760578 2019
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE We anticipate new treatments and clinical approaches will emerge for glioma and other cancer types as mechanistic and molecular studies on ATRX are only just beginning to reveal the many critical functions of this protein in cancer. 29889582 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations. 29521646 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease CTD_human Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. 23583981 2013