Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE ATRX in Diffuse Gliomas With its Mosaic/Heterogeneous Expression in a Subset. 26833422 2018
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. 28255664 2017
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Recent studies on gliomas have shown frequent alterations in the alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX). 28251430 2017
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE We highlight the genetic aberrations recently discovered in isocitrate dehydrogenase, alpha thalassemia/mental retardation syndrome X-linked, death-domain-associated protein, histone H3.3, and telomerase reverse transcriptase and discuss how these mutations lead to unexpected changes in the epigenetic landscape in gliomas. 25976256 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE We review the current state of diagnostic molecular markers for gliomas, focusing on isocitrate dehydrogenase 1 or 2 (IDH1/IDH2) gene mutation, α-thalassemia/mental retardation syndrome X-linked (ATRX) gene mutation, 1p/19q co-deletion and telomerase reverse transcriptase (TERT) promoter mutation in adult tumors, as well as v-raf murine sarcoma viral oncogene homolog B1 (BRAF) and H3 histone family 3A (H3F3A) aberrations in pediatric gliomas. 26948350 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas. 26210286 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE The results indicate immunohistochemical analysis including IDH1/2, ATRX, p53, and Ki-67 index is valuable for the classification of diffuse gliomas, which is useful for the evaluation of prognosis, especially Grade III gliomas and lower-grade gliomas (i.e., Grade II and III). 26968173 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE Our results showed ATRX-related regulatory functions of the combined profiles from DNA methylation and mRNA expression in astrocytic tumors, and delineated that loss of ATRX impacted biological behaviors of astrocytic tumor cells, providing important resources for future dissection of ATRX role in glioma. 25971279 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Tumor grade was correlated with the mutational load (the number of non-silent mutations) of the tumor: grade II diffuse gliomas harbour fewer genetic changes than grade III or IV, even within defined molecular subtypes (e.g.ATRX mutated diffuse gliomas). 26699864 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Tumor sequencing studies further indicate that acquired somatic mutations of TERT and ATRX are among the most frequent alterations found in adult gliomas. 26014050 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Loss of α-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated protein 6 (DAXX) expression has been implicated in the pathogenesis of alternative telomere lengthening in pancreatic endocrine neoplasm and glioma. 26022452 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. 26936505 2016
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells. 26055325 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE ATRX mutations have been identified in gliomas and are correlated with its loss of expression, which causes alternative lengthening of telomeres (ALT) leading to genomic instability. 24810474 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Those tumors that lacked LOH 1p19q showed a high frequency of IDH1 mutations and loss of alpha thalassemia/mental retardation syndrome X-linked gene (ATRX) immunoreactivity, indicating a possible phenotypic convergence of true oligodendrogliomas and gliomas of the alternative lengthening of telomeres (ALT) pathway. p53 alterations were common irrespective of the 1p19q status. 24444336 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Nearly all lower-grade gliomas with IDH mutations and no 1p/19q codeletion had mutations in TP53 (94%) and ATRX inactivation (86%). 26061751 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE All but 4 of 141 patients with loss of ATRX expression and diffuse glioma carried either IDH1 or IDH2 mutations. 25427834 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE Remarkably, on the basis of IDH mutation, 1p/19q codeletion, and ATRX expression, our study defined 4 molecularly and prognostically different groups of gliomas, showing the relevance of ATRX expression as a new marker for refining the molecular classification of gliomas and for distinguishing clinically distinct prognostic subgroups of patients. 25668564 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE When categorized according to the classification of Jiao et al., Olig2 LI of I-CF gliomas (cases with IDH and one or more of CIC, FUBP1 or combined 1p/19q loss; mean 71.0 %) was significantly higher than that of I-A gliomas (cases with IDH and ATRX alterations; mean 45.3 %). 25085214 2015
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease BEFREE Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas. 24559763 2014
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 Biomarker disease CTD_human The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. 24705251 2014
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 AlteredExpression disease BEFREE Mutation/loss of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) expression has been described in anaplastic gliomas. 23904111 2014
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the most common type of primary malignant brain tumors. 22869205 2013
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE In summary, our data show that ATRX alterations are frequent in adult diffuse gliomas and are specific to astrocytic tumors carrying IDH1/2 and TP53 mutations. 22886134 2013
Entrez Id: 546
Gene Symbol: ATRX
ATRX
0.400 GeneticVariation disease BEFREE Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma. 23104868 2013