|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
We showed that PGC-1α and NT-PGC-1α were decreased in MI-induced heart failure mice.
|
31133853 |
2019 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
We generated a cardiac specific PGC-1α knockout mice (KO) to specifically induce metabolic dysregulation typically accompanied by HF and performed a non-targeted LC-MS metabolite profiling analysis of heart, plasma, liver, and skeletal muscle to identify metabolites associated with cardiac specific metabolic remodelling.
|
29931052 |
2019 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
PGC-1α-cKO (cardiac-specific PGC-1α knockout) mice showed phenotypic similarity to the pressure-overload-induced heart failure model in wild-type mice, such as contractile dysfunction and downregulation of PGC-1α target genes, even under basal conditions.
|
30798619 |
2019 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, the present study demonstrated that NT‑PGC‑1α alleviated PE‑induced mitochondrial impairment and decreased lipid droplet accumulation in NRCMs, indicating that NT‑PGC‑1α may have ameliorated mitochondrial energy defects in NRCMs, and may be considered as a potential target for the treatment of heart failure.
|
29901150 |
2018 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
PGC-1α, a key regulator of energy metabolism, seems to be a relevant therapeutic target to rectify the energy deficit observed in heart failure (HF).
|
27876471 |
2017 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thermogenic genes expressions in epicardial adipose tissue (UCP1: OR 0.617, 95%CI 0.103-0.989, p=0.042; PGC1α: OR 0.416, 95%CI 0.171-0.912, p=0.031; PRDM16: OR 0.643, 95%CI 0.116-0.997, p=0.044) were showed as protective factors against the presence of heart failure with reduced left ventricular ejection fraction, and age (OR 1.643, 95%CI 1.001-3.143, p=0.026), presence of coronary artery disease (OR 6.743, 95%CI 1.932-15.301, p<0.001) and type-2-diabetes mellitus (OR 4.031, 95%CI 1.099-7.231, p<0.001) were associated as risk factors.
|
28824327 |
2017 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Metformin decreases the acetylation level of PGC-1α through up-regulating Sirt3, mitigates the damage to mitochondrial membrane potential of model of heart failure after myocardial infarction and improves the respiratory function of mitochondria, thus improving the cardiac function of mice.
|
28302481 |
2017 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.
|
22939990 |
2012 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
CTD_human |
Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes.
|
22503866 |
2012 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these findings suggest that the mitochondrial degeneration engaged in the skeletal muscle atrophy and the heart failure in the NF90 Tg mice may be caused by NF90-induced posttranscriptional repression of transcription factors such as PGC-1 and NRF-1 for regulating nuclear-encoded genes relevant to mitochondrial function.
|
22912857 |
2012 |
|
PPARGC1A
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These defects are independent of the downregulation of the PGC-1 expression suggesting novel mechanisms for mitochondrial dysfunction in heart failure.
|
20339121 |
2010 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
CTD_human |
Control by circulating factors of mitochondrial function and transcription cascade in heart failure: a role for endothelin-1 and angiotensin II.
|
19808358 |
2009 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
BEFREE |
This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
|
16511594 |
2006 |
|
PPARGC1A
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.
|
15297879 |
2004 |
|
PPARGC1A
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|