Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.030 Biomarker disease BEFREE We summarize the significant recent progress that has been made in treating heart failure in preclinically relevant animal models with AAV gene therapy and the recent results of clinical trials with cardiac AAV gene therapy for the treatment of heart failure. 28169951 2017
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.030 AlteredExpression disease BEFREE AAV gene delivery elevated the intracellular expression of the AR185 protein in a rat model of ischemic HF, and this treatment normalized the systolic and diastolic dysfunction of the failing myocardium <i>in vivo</i> by reversing myocardial Ca<sup>2+</sup> handling. 30885011 2019
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.030 Biomarker disease BEFREE Many molecular targets selected to treat heart failure using AAV gene therapy have been chosen because of their potential to regulate and restore cardiac contractility. 29703647 2018
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 Biomarker disease BEFREE Serum CEC mediated by PD and SR-BI, but not ABCA1 or ABCG1, significantly decrease in animals with HF (p<0.05 and p<0.005, respectively). 27980243 2017
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.020 Biomarker disease BEFREE RMP plays a protective role in chronic HF. 30590389 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.020 Biomarker disease BEFREE The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. 22116099 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 GeneticVariation disease BEFREE The aim of the present study was to evaluate the effects of ABCB1 gene polymorphism and P-gp inhibitor co-administration on steady-state digoxin serum concentration in congestive heart failure patients. 17377214 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 GeneticVariation disease BEFREE This study aimed to evaluate the influence of CYP3A5 and ABCB1 genotypes on tolvaptan pharmacokinetics and their relationships with plasma markers of CYP3A activity and laboratory test values in heart failure patients. 31652395 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 GeneticVariation disease BEFREE Effect of ABCB1 (MDR1) 3435C >T and 2677G >A,T polymorphisms and P-glycoprotein inhibitors on salivary digoxin secretion in congestive heart failure patients. 17652833 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 AlteredExpression disease BEFREE If so, screening for TCL1A and MDR1 SNPs or expression level in blood, might identify women at greatest risk of chemo-induced heart failure. 23630447 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 GeneticVariation disease BEFREE In conclusion, an association between ABCB1 haplotype and plasma fasting LDL cholesterol concentration was found in patients with advanced heart failure. 21445698 2011
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.030 GeneticVariation disease BEFREE This study included a randomly selected subcohort (n=502), cardiovascular disease (CVD) cases (n=245), and heart failure cases (n=220) from the Health, Aging, and Body Composition (Health ABC) Study. 29602632 2018
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.030 Biomarker disease BEFREE In patients without HF at baseline (89.9%), we derived the 5-year risk for incident HF using the 9-variable Health ABC HF Risk score [classified as low-to-average (<10%), high (10-20%), and very high (≥ 20%)]. 29020355 2018
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.030 GeneticVariation disease BEFREE In this study, we included Health ABC study (Health, Aging, and Body Composition) participants without prevalent HF who had arterial stiffness measured as carotid-femoral pulse wave velocity (cf-PWV) at baseline (n=2290). 27993954 2017
Entrez Id: 22
Gene Symbol: ABCB7
ABCB7
0.010 Biomarker disease BEFREE ABCB7 was found to interact with mitochondrial complexes IV and V. We conclude that in chronic pressure overload, ABCB7 deficiency results in iron overload and mitochondrial dysfunction, contributing to heart failure. 31511561 2019
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.010 GeneticVariation disease BEFREE Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01). 23927520 2013
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 Biomarker disease HPO
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.110 GeneticVariation disease CLINVAR
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.110 Biomarker disease BEFREE We also analyzed the mRNA expression of the K(ATP) targets K(ir)6.1, K(ir)6.2, SUR1, and SUR2 in the left atria and ventricles of NF (n=8) and CHF (n=4) hearts. 21586291 2011
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.020 GeneticVariation disease BEFREE Scanning of genomic DNA from individuals with heart failure and rhythm disturbances due to idiopathic dilated cardiomyopathy identified two mutations in ABCC9, which encodes the regulatory SUR2A subunit of the cardiac K(ATP) channel. 15034580 2004
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
0.020 Biomarker disease BEFREE We also analyzed the mRNA expression of the K(ATP) targets K(ir)6.1, K(ir)6.2, SUR1, and SUR2 in the left atria and ventricles of NF (n=8) and CHF (n=4) hearts. 21586291 2011
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.010 Biomarker disease BEFREE The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. 22116099 2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.010 Biomarker disease BEFREE In addition, the study highlighted the role of ABL tyrosine kinases in CF caused by anticancer PKIs. 28098949 2017
Entrez Id: 28
Gene Symbol: ABO
ABO
0.010 Biomarker disease BEFREE ABO blood type distribution in the HF population was not significantly different to that reported in the general national population (A 40%, B 20%, AB 8%, and O 33%). 29958715 2018
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.310 Biomarker disease CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611 2016