Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4967
Gene Symbol: OGDH
OGDH
0.010 AlteredExpression disease BEFREE Investigating succinyl CoA generation, enzyme activity assays demonstrated that α-ketoglutarate dehydrogenase and succinate dehydrogenase activities were significantly decreased in ischemic heart failure. 31836543 2020
Entrez Id: 10072
Gene Symbol: DPP3
DPP3
0.010 Biomarker disease BEFREE Our results suggest that DPP3 could be a new biomarker and biotarget for severe HF. 31472040 2020
Entrez Id: 11019
Gene Symbol: LIAS
LIAS
0.010 Biomarker disease BEFREE A progressive impairment in exercise LA mechanics combined with limited cardiac output increase and right ventricular-to-pulmonary circulation uncoupling was observed from primary to secondary MR. LAS during exercise was predictive of all-cause mortality and hospitalization for heart failure. 30878440 2020
Entrez Id: 170690
Gene Symbol: ADAMTS16
ADAMTS16
0.010 AlteredExpression disease BEFREE Western blot and qRT-PCR analyses demonstrated that ADAMTS16 was significantly up-regulated in mice with transverse aortic constriction (TAC) associated with left ventricular hypertrophy and heart failure, which was correlated with increased expression of Mmp2, Mmp9, Col1a1 and Col3a1. 31297506 2020
Entrez Id: 57492
Gene Symbol: ARID1B
ARID1B
0.010 GeneticVariation disease BEFREE The present study was a subanalysis of the BRIGHT-D study that focused on the effects of bisoprolol vs carvedilol on inflammation and oxidative stress in CHF patients. 31444140 2020
Entrez Id: 6442
Gene Symbol: SGCA
SGCA
0.010 Biomarker disease BEFREE We reviewed 297 elderly HF patients with independent basic ADL before hospitalization.Patients with prior HF were excluded. 31489463 2020
Entrez Id: 91012
Gene Symbol: CERS5
CERS5
0.010 AlteredExpression disease BEFREE Moreover, CerS1 and CerS5 mRNA expression was also reduced in muscle biopsies from patients in advanced stage of chronic heart failure (CHF) suffering from muscle wasting and frailty. 31692231 2020
Entrez Id: 10715
Gene Symbol: CERS1
CERS1
0.010 AlteredExpression disease BEFREE Moreover, CerS1 and CerS5 mRNA expression was also reduced in muscle biopsies from patients in advanced stage of chronic heart failure (CHF) suffering from muscle wasting and frailty. 31692231 2020
Entrez Id: 84890
Gene Symbol: ADO
ADO
0.010 Biomarker disease BEFREE Here, we investigated the role of A1R signaling at physiologically relevant ADO concentrations on HF SAN pacemaker cells. 31751583 2020
Entrez Id: 1577
Gene Symbol: CYP3A5
CYP3A5
0.010 GeneticVariation disease BEFREE This study aimed to evaluate the influence of CYP3A5 and ABCB1 genotypes on tolvaptan pharmacokinetics and their relationships with plasma markers of CYP3A activity and laboratory test values in heart failure patients. 31652395 2020
Entrez Id: 1820
Gene Symbol: ARID3A
ARID3A
0.010 GeneticVariation disease BEFREE The present study was a subanalysis of the BRIGHT-D study that focused on the effects of bisoprolol vs carvedilol on inflammation and oxidative stress in CHF patients. 31444140 2020
Entrez Id: 23762
Gene Symbol: OSBP2
OSBP2
0.010 Biomarker disease BEFREE Such a holistic approach based on the HLM staging system and multimodality imaging can provide a global assessment of patient features allowing for targeted therapies and better heart failure management. 31317296 2020
Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
0.010 Biomarker disease BEFREE <b>Conclusions:</b> Taken together, our study elucidates a novel role for PDE10A in the regulation of pathological cardiac remodeling and development of heart failure. 31801360 2020
Entrez Id: 1576
Gene Symbol: CYP3A4
CYP3A4
0.010 AlteredExpression disease BEFREE This study aimed to evaluate the influence of CYP3A5 and ABCB1 genotypes on tolvaptan pharmacokinetics and their relationships with plasma markers of CYP3A activity and laboratory test values in heart failure patients. 31652395 2020
Entrez Id: 3485
Gene Symbol: IGFBP2
IGFBP2
0.010 Biomarker disease BEFREE In 3 international cohorts, IGFBP2 level is a strong prognostic factor for cardiovascular mortality in HF, adding information to natriuretic monitoring and usual clinical markers, that should be further prospectively evaluated for patients' optimized care. 31806281 2020
Entrez Id: 50508
Gene Symbol: NOX3
NOX3
0.010 AlteredExpression disease BEFREE This increase in NOX3 may also be responsible, at least in part, for the reported increase in ROS levels in heart failure. 30897339 2019
Entrez Id: 10411
Gene Symbol: RAPGEF3
RAPGEF3
0.010 Biomarker disease BEFREE This study aims to explore the effect of Exchange-protein activated by cAMP 1 (EPAC1) on AF in isoproterenol (ISO)-induced HF and the potential molecular mechanism. 30915767 2019
Entrez Id: 340371
Gene Symbol: NRBP2
NRBP2
0.010 Biomarker disease BEFREE The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy. 31009519 2019
Entrez Id: 54541
Gene Symbol: DDIT4
DDIT4
0.010 Biomarker disease BEFREE In the present study the potential contribution of Redd1 overexpression to the chronic phase of heart failure after myocardial infarction (MI) was explored and the mechanisms underlying Redd1 actions were determined. 31638187 2019
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.010 Biomarker disease BEFREE Furthermore, multiple clinical studies have identified TRAIL or DR5 as biomarkers in the prediction of severity and mortality following myocardial infarction and in heart failure development risk suggesting a role of DR5 signaling in the heart. 31473246 2019
Entrez Id: 100379251
Gene Symbol: NPPA-AS1
NPPA-AS1
0.010 AlteredExpression disease BEFREE Expression of ANP mRNA and NPPA-AS1 was increased and correlated in isolated strained human cardiomyocytes and in hearts from patients with advanced heart failure. 31503546 2019
Entrez Id: 2833
Gene Symbol: CXCR3
CXCR3
0.010 AlteredExpression disease BEFREE Heart failure (HF) is associated in humans and mice with increased circulating levels of CXCL9 and CXCL10, chemokine ligands of the CXCR3 receptor, predominantly expressed on CD4+ Th1 cells. 30779709 2019
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
0.010 Biomarker disease BEFREE Furthermore, CDDO-Me reduced NF-<i>κ</i>B binding and increased Nrf2 binding to the CREB-binding protein, which may contribute to the selective increase of Nrf2 downstream targets, including NADPH Oxidase Quinone 1, Heme Oxygenase 1, Catalase, and Glutamate-Cysteine Ligase Catalytic Subunit, and the attenuation of myocardial inflammation in CHF rats. 31601682 2019
Entrez Id: 55850
Gene Symbol: USE1
USE1
0.010 Biomarker disease BEFREE Metformin Use Is Associated With a Lower Risk of Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus: a Retrospective Cohort Analysis. 31630591 2019
Entrez Id: 120425
Gene Symbol: JAML
JAML
0.010 Biomarker disease BEFREE The AMICA trial (Atrial Fibrillation Management in Congestive Heart Failure With Ablation) did not reveal any benefit of catheter ablation in patients with AF and advanced HF. 31760819 2019