Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE Strikingly, these mice show a rapid decrease in cardiac contractility and a rapid loss of SERCA2 protein, which is also seen in heart failure. 30575439 2019
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Our results highlight the interaction of Yulink with PPARγ in regulating Serca2 expression and suggest a mechanistic role of the Yulink in the development of human heart failure and SCD.-Tsai, C.-T., Kuo, M.-W., Lin, J.-L., Yu, A. L., Yu, J. 29401584 2018
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE Our findings show a crucial role of LRP1/Pyk2/HIF-1α in hypoxia-induced cardiomyocyte SERCA2 downregulation, a pathophysiological process closely associated with heart failure. 25968337 2015
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 GeneticVariation disease BEFREE These data reveal myofibrillar Ca(2+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions. 26064889 2015
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease BEFREE In this review we describe the drugs adopted in clinical practice that activate SERCA2a/b function as well as new promising therapeutic tools using SERCA2 viral gene delivery to improve cardiac function and treat heart failure. 24361307 2014
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE A reduced activity and expression of SERCA2 protein have been described in heart failure and diabetic cardiomyopathy, resulting in an altered Ca(2+) handling and cardiac contractility. 25270119 2014
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 GeneticVariation disease BEFREE The observation that ATP2A2 rs1860561 gene variant associated with lower risk of life-threatening arrhythmia in HF patients suggests that selected calcium gene variants may modify the risk of SD even within the complex and polygenic pathological condition of HF. 24048583 2013
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease RGD Protective effect of oxymatrine on chronic rat heart failure. 21691940 2011
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease CTD_human Differential contractile impairment of fast- and slow-twitch skeletal muscles in a rat model of doxorubicin-induced congestive heart failure. 19776660 2009
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Therapeutic upregulation of SERCA2 expression using replication deficient adenoviral expression vectors, pharmacological interventions using thyroid hormone analogues, beta-adrenergic receptor antagonists, and novel metabolically active compounds are currently under investigation for the treatment of uncompensated cardiac hypertrophy and heart failure. 16902596 2006
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE This finding led us to explore the expression of the presently known cardiac Ca2+-ATPase isoforms in heart failure. 16402920 2006
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure. 10468529 1999
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE During end-stage human heart failure, we have demonstrated that type 1 IP3R (IP3R1) mRNA and protein levels are up-regulated, in contrast to other cardiac calcium regulatory proteins, such as the type 2 ryanodine receptor (RYR2) and type IIa sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA2), which are down-regulated. 9476544 1997
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 AlteredExpression disease BEFREE These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2. 8689655 1996
Entrez Id: 488
Gene Symbol: ATP2A2
ATP2A2
0.800 Biomarker disease GENOMICS_ENGLAND