Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE The interplay of tumour necrosis factor-α (TNF-α) and oxidative stress was related to severities of coronary atherosclerosis and congestive heart failure. 31494339 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE Expression levels of IL-1ß, IL-6, TNF-alpha, and BAX mRNA were significantly associated with the degree of CHF. 30968846 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Tumor necrosis factor-α (TNF-α) is a biomarker of inflammation that occurs in patients suffering from heart failure (HF). 30744018 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Adult male wild-type C57BL/6 mice, Foxp3-diphtheria toxin receptor transgenic mice, and tumor necrosis factor (TNF) α receptor-1 (TNFR1)<sup>-</sup><sup>/-</sup> mice underwent nonreperfused myocardial infarction to induce HF or sham operation. 30586716 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-<i>α</i>, IL-6, IL-8, IL-10, IL-1<i>α</i>, IL-1<i>β</i>, IL-2, TGF-<i>β</i>, and IFN-<i>γ</i>. 31275453 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE In addition, the levels of IL-6, TNF-α and IL-1β decreased to 154.41 ± 7.72 pg/mg protein, 110.02 ± 6.96 pg/mg protein and 39.39 ± 5.27 pg/mg protein, respectively; the relative activity of p38 MAPK decreased to 2.60 ± 0.40 in CHF + SOJ group. 30860934 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful. 31087601 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE In this review, we describe available data on the occurrence of adverse events associated with TNF inhibitor treatment in ankylosing spondylitis, including serious adverse events, infections, serious infections, tuberculosis, opportunistic infections, hepatitis B reactivation, malignancies, laboratory test abnormalities, autoimmune diseases, paradoxical adverse events, and heart failure. 30476367 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE Patients with MI and HF had reduced serum irisin, LVEF, and HDL-C and higher levels of BMI, WHR, SBP, DBP, troponin-I, creatine kinase-MB (CK-MB), TNF-α, TC, TGs, and LDL-C compared with control. 30958967 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE The protective and anti-inflammatory effects of TNFR2 may explain why TNF inhibitors failed to be effective in diseases such as heart failure or multiple sclerosis, where TNF has been strongly implicated as a driving force. 30856027 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE Last, PNA5 treatment decreased VCID/HF-induced activation of brain microglia/macrophages and inhibited circulating tumor necrosis factor <i>α</i>, interleukin (IL)-7, and granulocyte cell-stimulating factor serum levels while increasing that of the anti-inflammatory cytokine IL-10. 30709867 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE A functional analysis of T cells from patients with acute HF revealed that the CD4<sup>+</sup>CD57<sup>+</sup> T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4<sup>+</sup>CD57<sup>-</sup> T cell population. 31501486 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE The elevated level of TNF-α in the brain and circulation in heart failure (HF) suggests an increase in the TACE-mediated ectodomain shedding process. 31154904 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE There was a positive correlation between TNFα and IL-6 levels in CHF patients and severity of CHF in patients. 28889349 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy. 29175266 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure. 30556887 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Tumor necrosis factor-α (TNF-α) contributes to the genesis of heart failure and impairs mitochondria. 29613828 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease RGD ExT reduced by 59% TNF-α level in Tr-HF group (MD -1.7; 95% CI -2.9 to -0.3) and increased IL-10 (MD 15; 95% CI 11-26) when compared with the Sed-HF group. 28939262 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE The role of TNF in CHF and RA differs substantially with regard to the source and pathophysiological function of the cytokine in both conditions, therefore negative data from CHF studies should be interpreted with caution. 29895751 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers. 30259192 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Decreased anabolism because of alterations in the insulin-like growth factor 1 (IGF-1)/growth hormone (GH) axis and increased catabolism induced by proinflammatory cytokines like tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) have been reported to contribute to muscle wasting in chronic heart failure (CHF). 28695463 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. 28793058 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 AlteredExpression disease BEFREE RT-PCR showed that the mRNA expressions of TNF-α, Fas and FasL in heart failure group were significantly higher than those in normal group. 28925471 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Despite these well-described observations, less is known about the mechanistic underpinnings of proinflammatory cytokines especially TNFα in pathogenesis of HF. 28763371 2017