Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. 28371822 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE In this report, we used real-time PCR assay to compare relative gene expression of TNFα and IL-6 in PBMC from CHF patients with various heart diseases (n = 42, EF < 45%, NYHA I to IV) and matched healthy control subjects (n = 42).We also determined the TNFα and IL-6 concentrations of cell culture supernatant of PBMCs with ELISA. 28889349 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE We investigated whether peripheral expression of the proinflammmatory factors, TNF-α and IL-6 can predict variable of clinical assessment of patients with CHF. 28889349 2018
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 Biomarker disease BEFREE Increased Atrial β-Adrenergic Receptors and GRK-2 Gene Expression Can Play a Fundamental Role in Heart Failure After Repair of Congenital Heart Disease with Cardiopulmonary Bypass. 28214967 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE ACE-Inhibition Benefit on Lung Function in Heart Failure is Modulated by ACE Insertion/Deletion Polymorphism. 26847573 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker disease BEFREE Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure. 28810263 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Angiotensin-Converting Enzyme ID Polymorphism in Patients with Heart Failure Secondary to Chagas Disease. 28977050 2017
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker disease BEFREE There is an ANG II/AT1R/HoxD10/miR-7b/GABBR1 pathway in the PVN that contributes to sympathoexcitation and deterioration of cardiac function in CHF. 26699387 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE To explore the association between ACE gene insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH) in patients with hypertension who have developed heart failure with preserved ejection fraction (HFpEF). 26861937 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Pharmacogenetic Risk Stratification in Angiotensin-Converting Enzyme Inhibitor-Treated Patients with Congestive Heart Failure: A Retrospective Cohort Study. 26633885 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Moreover, heart failure patients with high plasma Nampt levels showed suppressed cardiac TNF-α and IL-6 mRNA expression after 6 months' follow-up as well as lower B-type natriuretic peptide levels compared with heart failure patients with low Nampt plasma concentrations. 25498756 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Chronic heart failure (CHF) increases sympathoexcitation through angiotensin II (ANG II) receptors (AT1R) in the paraventricular nucleus (PVN). 26699387 2016
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.600 AlteredExpression disease BEFREE We found that thrombin-induced COX-2 expression, PGE2 release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. 26385185 2016
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 Biomarker disease CTD_human Conversely, the dual-specific GRK2 and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg-regulated genes. 26670611 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE In the CRS1 group, the mRNA expression of IL-6, IL-18 and NGAL resulted significantly higher in TECs incubated with CRS1 plasma compared with those incubated with plasma from HF and CTR (p < 0.01). 26228789 2016
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 Biomarker disease BEFREE Over the last 20years, the role of GRK2 in HF has been widely studied. 26829117 2016
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 Biomarker disease CTD_human Here, we investigated whether inhibition of G-protein-coupled receptor kinase 2 (GRK2) could counteract the disturbed substrate metabolism of late-stage heart failure. 26670611 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE A recent heart failure (HF) drug, LCZ696 (Entresto(TM)), that combines a neprilysin inhibitor and an angiotensin II receptor inhibitor was suggested to augment circulating B-type natriuretic peptide (BNP) concentrations, making the results of BNP measurements diagnostically ambiguous. 26864319 2016
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.600 Biomarker disease BEFREE Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the β1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. 26796036 2016
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 AlteredExpression disease BEFREE We also show human data consistent with MR activation status in heart failure influencing GRK2 levels. 26932512 2016
Entrez Id: 156
Gene Symbol: GRK2
GRK2
0.600 Biomarker disease CTD_human The development of disturbed substrate utilization of FASN transgenic cardiomyocytes and signs of heart failure were retarded by the transgenic expression of GRKInh, a peptide inhibitor of GRK2. 26670611 2016
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.600 AlteredExpression disease BEFREE ANP and BNP mRNA expressions were higher while CNP was lower in end-stage HF LV. 25117468 2015
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.600 Biomarker disease BEFREE Enrolled patients will be at high risk for recurrent heart-failure hospitalizations by virtue of having elevated N-terminal pro-B-type natriuretic peptide/BNP (>1,200 pg/ml, or >1,600 pg/ml if atrial fibrillation is present) and/or recent heart failure hospitalization. 24622121 2015
Entrez Id: 4878
Gene Symbol: NPPA
NPPA
0.600 Biomarker disease BEFREE The atrium is the major site of ANP synthesis, which has been said to increase in heart failure as a result of increased production in the left ventricular (LV) myocardium. 24599027 2015
Entrez Id: 4878
Gene Symbol: NPPA
NPPA
0.600 AlteredExpression disease BEFREE ANP and BNP mRNA expressions were higher while CNP was lower in end-stage HF LV. 25117468 2015