Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE Our assay method does not require HBV infection or radioactive <sup>3</sup>H-TCA and provides a facile way to identify viral entry inhibitors via measuring bile acid transport activity of NTCP. 31722821 2020
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Human NTCP transgenic mouse still could not support productive HBV infection, and humanized mouse liver with human hepatocytes which supported whole HBV life cycle still dominates HBV infection in vivo, a value but expensive model until now. 31741335 2020
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Additionally, NTCP located in the hepatocyte membrane is the portal for hepatitis B and D virus (HBV/HDV) infections. 31140111 2020
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE Sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the surface of human hepatocytes and functions as an entry receptor of hepatitis B virus (HBV). 31836663 2020
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats. 30541833 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE In addition, HBV DNA level was suppressed when anti-HBV medicine Entecavir (ETV) introduced into HepG2-NTCP 3D system. 30963688 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE The study highlighted the role of the SLC10A1 S267F variant in the loss of the ability to support HBV infection and taurocholate transport activity. 31177598 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Moreover, the aa 158 sequence determined attachment of the HBV envelope protein to the host cell, demonstrating the mechanism whereby HBV infection would create positive selection at this NTCP residue. 30541857 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection. 30809790 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target the sodium-taurocholate cotransporting polypeptide (NTCP; <i>SLC10A1</i>) on the sinusoidal membrane of hepatocytes. 31333191 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE Analysis of Hepatitis B Virus Reactivation After Radiotherapy in Patients With Hepatocellular Carcinoma Using the Lyman NTCP Model. 31526114 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for hepatitis B virus (HBV) entry. 30952782 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE We recently found that human hepatoma cell line Li23-derived cells overexpressing NTCP (A8 cells subcloned from Li23 cells), whose gene expression profile was distinct from that of HepG2/NTCP cells, were also sensitive to HBV infection. 31133379 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE In this study, down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes was found to prevent HBV infection in HepG2-NTCP-tet cells and in liver-humanized mice. 31179847 2019
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Human NTCP as well as the Ntcps from the great apes chimpanzee and orangutan showed transport-competing binding of HBV derived myr-preS1-peptides. 29912972 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses. 30097692 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE These results indicated that fasiglifam only affect on HBV infection via NTCP inhibition. 29723527 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Moreover, exogenous treatment of AA inhibits HBV infection in HepG2-NTCP cells. 29437960 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. 29456407 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV). 30050063 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Our findings uncover a novel role for NTCP in the HBV life cycle and provide a reference for the use of novel NTCP-targeting entry inhibitors to suppress HBV infection and replication. 30459339 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated. 29300980 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE The HepG2-NTCP cells expressing the sodium taurocholate cotransporting polypeptide (NTCP) receptor are susceptible to HBV infection. 30275764 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE This study advances our understanding of NTCP-mediated HBV infection. 30032030 2018
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE To further improve cell culture systems of HBV infection and replication, we constructed NTCP-expressing HepG2 and AML12 cell lines that are highly permissive to HBV infection. 30232184 2018