Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE This study aims to investigate the antiviral effect of polyethylene glycol (PEG)-interferon α-2a and PEG-interferon α-2b treatment on hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) at the 48th week of treatment and the 24th and 48th week after withdrawal, in order to provide guidance on the antiviral treatment of HBeAg-positive CHB patients. 29055925 2018
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 Biomarker disease CTD_human Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human. 28545106 2017
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE IgG antibodies from BM32-vaccinated but not of HBV-infected individuals recognized the sequence motif implicated in NTCP (sodium-taurocholate co-transporting polypeptide)-receptor interaction of the hepatitis B virus and inhibited HBV infection. 27568223 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Association between IFN-γ genetic polymorphisms and susceptibility to hepatitis B virus infection: A meta-analysis. 26458193 2017
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population. 26968990 2016
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Recent studies have demonstrated an essential role of sodium-taurocholate cotransporting polypeptide as a functional receptor in HBV infection, which has facilitated the development of novel infection systems and opened the way for more detailed understanding of the early steps of HBV infection as well as a potential new therapeutic target. 26414381 2016
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 GeneticVariation disease BEFREE Association of the gene polymorphisms in sodium taurocholate cotransporting polypeptide with the outcomes of hepatitis B infection in Chinese Han population. 25010264 2016
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 Biomarker disease BEFREE Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122. 26409216 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The results indicated a statistically significant association between the IFN-γ +874T/A polymorphism and hepatitis virus-related diseases in a recessive gene model (AA vs. TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity). 25939029 2016
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE Recent advances in our understanding of HBV biology, such as the discovery of the bile-acid pump sodium-taurocholate cotransporting polypeptide (NTCP) as a receptor for HBV, enabled the establishment of NTCP expressing hepatoma cell lines permissive for HBV infection. 26784218 2016
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease BEFREE A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide. 26378168 2016
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 AlteredExpression disease BEFREE Serum also contains microRNAs, a class of small non-coding RNAs that play an important role in regulating gene expression. miR-122 is specific to the liver and correlates strongly with liver enzyme levels and necroinflammatory activity, and other microRNAs are correlated with the degree of fibrosis. miR-122 has also been found to be required for hepatitis C virus (HCV) infection, whereas other microRNAs have been shown to play antiviral roles. miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV) transcripts, and others are up- or down-regulated in infected individuals. 26927063 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.400 Biomarker disease BEFREE The hepatitis B serological markers and viral loads were tested every 3 months until 1 year after stopping Peg-IFN therapy. 25835020 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE The results suggest that IL-18 -137C/G, TNF-308 G/A and IFNγ +874 A/T SNPs were associated to more severe liver injury in chronic HBV infection. 25952099 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.400 Biomarker disease BEFREE In contrast, in HBV several retrospective studies yielded conflicting results of the association of IL28B with PEG-IFN-induced treatment response. 26284971 2016
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 AlteredExpression disease BEFREE Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus. 25766860 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The frequency of HBV-specific T cells producing IFN-γ after stimulation with HBV epitopes was similar in CHB and RHB patients. 26526193 2016
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
0.400 AlteredExpression disease BEFREE Our study thereby reveals that under the unique condition of high abundance of miR-122 and viral mRNAs and much lower level of miR-122 target in HBV infection, HBV may have evolved to employ the miRNA-mediated virus and host mRNAs network for optimal fitness within hepatocytes. 26184825 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.400 AlteredExpression disease BEFREE Knockdown of FN expression significantly inhibited HBV DNA replication and protein synthesis through activating endogenous IFN-α production. 27023403 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.400 GeneticVariation disease BEFREE Interaction of TLR-IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese. 25469587 2016
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.400 Biomarker disease BEFREE A total of 210 patients with chronic hepatitis C genotype 1 of high viral load (baseline serum hepatitis C virus RNA > 5.0 log10 IU/mL) were divided into two groups by type of treatment: triple therapy with telaprevir, pegylated-interferon-α (PEG-IFNα), and ribavirin (RBV) for 24 wk (n = 88), or dual therapy with PEG-IFNα and RBV for 48 wk (n = 122). 25914481 2016
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease CTD_human This is the first demonstration showing host regulation of NTCP to support HBV infection. 25550158 2015
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease CTD_human Sodium taurocholate cotransporting polypeptide (NTCP) is an entry receptor for hepatitis B virus (HBV) and is regarded as one of the determinants that confer HBV permissiveness to host cells. 25550158 2015
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 AlteredExpression disease BEFREE The up-regulation of NTCP expression and restoration of hepatocyte-like polarity in our hydrogels also shed light on future study of hepatitis B virus infection in vitro. 24857292 2015
Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
0.400 Biomarker disease CTD_human Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. 25550158 2015