Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE IFNL4 genotype has also been linked to variation within the HCV genome, as well as risk of hepatic fibrosis, certain cancers and some infectious disease. 31846709 2020
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 Biomarker disease BEFREE Changes in LDL among CHC patients who achieved SVR differed by IFNL4 genotype, which implicates the interferon-λ4 protein in metabolic changes observed in HCV-infected patients. 31504644 2020
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 Biomarker disease BEFREE Interferon lambda 4 (IFNλ4) has been recently known and studied for its role in hepatitis C virus (HCV) infection, but its clinical potential is significantly hampered due to its poor expression in vitro. 31479875 2020
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Compared to patients without OCI, unfavorable IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ∆G/∆G genotypes were more frequently reported in OCI patients. 31838260 2020
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE The finding that a "knock-out" allele for IFN-λ4 enhances HCV clearance challenges the paradigm of IFNs as antiviral cytokines. 31161939 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Genetic variants within the <i>IFNL</i> region, including those controlling production and activity of IFN-λ4, have been strongly associated with clearance of hepatitis C virus (HCV) infection. 31070498 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE We show that genetic variants within the IFN lambda 4 (<i>IFNL4</i>) locus are the major factors associated with the studied traits, accordingly with observations in other HCV genotypes and with comparable effect sizes. 31260374 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Strong linkage disequilibrium of IFNL4 rs12979860 with IFNL4 rs368234815, which is casually associated with HCV spontaneous and therapeutical eradication, at least partially explains favorable HCV outcomes attributed to major homozygosity in rs12979860. 30027841 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 Biomarker disease BEFREE Although the ability to produce IFN-λ4 is associated with decreased HCV clearance, the recombinant IFN-λ4 is active against HCV and other viruses. 31241411 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection. 30289470 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 Biomarker disease BEFREE Here, we examined the role played by interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays a crucial role in spontaneous clearance or establishment of chronicity following acute infection. 31478835 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE In the meta-analysis, significant associations with HCV clearance were confirmed at the interferon lambda gene locus IFNL4-IFNL3 (19q13.2) (P = 5.99 × 10<sup>-50</sup>) and the MHC locus 6p21.32 (P = 1.15 × 10<sup>-21</sup>). 30593799 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI. 30821879 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease GWASCAT Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients. 31260374 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease GWASCAT Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus. 30593799 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE The relationship between IFNL4 genotype and the rate of fibrosis in hepatitis C patients. 31479286 2019
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 AlteredExpression disease BEFREE Comparison of published gene expression data from humans and chimpanzees showed that this difference in activity between K154 and E154 in IFNλ4 correlates with differences in antiviral gene expression in vivo during HCV infection. 30308076 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE The recently described rs368234815 TT/ΔG dinucleotide and rs117648444 nonsynonymous rs117648444" genes_norm="101180976;282617">P70S polymorphisms in IFN lambda 4 (IFNL4) gene, which are strongly associated with response to IFN in hepatitis C virus (HCV) infection, could be also useful in IFN-treated CHB patients. 28732143 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Impact of IFNL4-∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals. 29866411 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE In chronic hepatitis C virus (HCV) infections, where the IFNL variants were first identified to be associated with response to interferon-α-ribavirin therapy, the available data clearly suggests that the causal variant could be the dinucleotide polymorphism rs368234815 that causes an open reading frame-shift in the IFNL4 gene resulting in expression of a functional IFN-λ4, a new type III IFN. 29705128 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection. 29165633 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 Biomarker disease BEFREE Impact of Interferon Lambda 4 Genotype on Interferon-Stimulated Gene Expression During Direct-Acting Antiviral Therapy for Hepatitis C. 29534310 2018
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 AlteredExpression disease BEFREE In summary, intrahepatic expression of IFNL4 was associated with increased antiviral ISG expression and decreased suppressive ISG expression at baseline, resulting in poor responsiveness to IFNα-based therapy in HCV infection. 28036111 2017
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE The IFNL4 rs368234815 polymorphism plays a prominent role in spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. 28057801 2017
Entrez Id: 101180976
Gene Symbol: IFNL4
IFNL4
0.200 GeneticVariation disease BEFREE Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. 28186161 2017