Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The cytolysis of HCV-infected hepatocytes is mediated by perforin and granzyme B secreted by cytotoxic T lymphocyte (CTL) and natural killer (NK) cells, whereas noncytolytic HCV clearance is mediated by interferon gamma (IFN-γ) secreted by CTL and NK cells. 31027278 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Our data show that NK cells from HCV+ patients have an unbalanced ability to produce IFNγ and to kill target cells in haplotype A and B carriers, suggesting the existence of complex functional differences governed by KIR-HLA interaction, particularly on KIR3DL1 expressing NK cells. 31177636 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Treatment of Huh7.5 cells with a MEK/ERK inhibitor abrogated the anti-HCV effects of IL-15 and IFN-γ and overexpression of ERK1 prevented HCV replication compared to control transfection. 29908921 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE In this context, anti-RR antibodies were detected by IFI on HEp-2 cells in 142 patients under ribavirin therapy (G1: 74 patients with a positive posttreatment HCV-PCR and G2: 68 patients with a negative posttreatment HCV-PCR, matched in age and gender), 84 kidney transplant recipients (KTRs) under mycophenolate and 158 controls (30 with systemic lupus erythematosus, 37 with rheumatoid arthritis, and 91 healthy blood donors). 31081724 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE However, M1 macrophages from HCV-infected individuals significantly decreased IFN-γ expression in CD8<sup>+</sup> T-cells. 31027182 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Interestingly, NK cell line NK-92 induced cytotoxicity and interferon-γ mRNA expression and subsequently reduced the levels of HCV RNA replication during co-culture with HCV-infected RSc cells. 29511613 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Moreover, a lower frequency of IFN-γ producing Vγ9Vδ2 T-cells was observed in the liver of HCV<sup>pos</sup> patients, suggesting a functional impairment in the cytokine production in HCV<sup>pos</sup> liver. 29029951 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE ALT = alanine transaminase; BP = blood pressure; CI = confidence interval; HCV = hepatitis C virus; HR = hazard ratio; IFG = impaired fasting glucose; NAFLD = nonalcoholic fatty liver disease; ULN = upper limit of normal. 29975579 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE Interferon gamma and interleukin 8 gene polymorphisms in patients with hepatitis C virus related oral lichen planus. 30290294 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Although T-cell secretion of interferon gamma was required to inhibit HCV replication, the HBV-specific TCR-reprogrammed resting T cells reduced HBV replication also through intracellular activation of apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3). 29550589 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE A total of 427 HCV sero-reactive thalassemic individuals were processed for HCV viral genomic diversity and host gene polymorphisms analysis of TNF-α (-308 A/G) and IFN-γ (+874 A/T). 29196132 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE An observational case-control study was performed to identify such parameters, peripheral blood mononuclear cells from 57 children with chronic HCV were systemically phenotyped, and the serum level of Interferon gamma and interleukin (IL) -17 was measured. 30022474 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Moreover, results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-α, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-γ after post-treatment. 30031388 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE HCV-specific T cell responses were analyzed by interferon gamma using an enzyme-linked immunospot assay and 3H-thymidine incorporation assay.HCV antibodies were also analyzed. 28953534 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Serum interferon-gamma-inducible protein-10 (IP-10) is elevated in cholestatic liver diseases and predicts response to antiviral therapy in patients with chronic hepatitis C virus (HCV) infection. 30507970 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Increased levels of chemokine interferon-gamma (IFN-γ)-inducible protein-10 (CXCL10), soluble CD163 (sCD163) and soluble CD14 (sCD14) have been reported in HCV infection. 28636655 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Most HCV T cell epitopes that elicited an IFN-γ response in the source did not in the recipient, despite the pair sharing human leukocyte antigen alleles that govern antigen presentation and similar autologous viruses. 28530508 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE More importantly, NK cells in co-infection displayed a highly impaired functional activity with significantly lower IFN-γ production and degranulation than in healthy donors as well as HIV and HCV mono-infection, suggesting a synergistic effect of both viruses. 28380039 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation disease BEFREE However, no significant association was observed between the cytokines (IL-10 and IFN-γ) genotypes profile and HCV-liver cirrhosis risk in the studied population, except for the high frequency of IFN-γ +874 T allele in cirrhotic patients. 28387594 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The rgFLU-HCV<sub>CE1E2</sub> virus also stimulated IFN-γ production by virus-specific peripheral blood mononuclear cells in patients with chronic HCV infection. 28778831 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE These results show that IFN-α stimulates IFN-γ expression in type 1 NKT cells and enhances the inhibition of HCV replication. 28253324 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE The antiviral effect of IFN-α<sub>2</sub> on DAA-resistant HCVs was weaker than that of IFN-γ and IFN-λ<sub>1</sub>. 28864074 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE IFN-γ+874  AA and IL-10-1082 AA had an antagonistic effect (p<0.01) on the clinical progression, including asymptomatic HBV and HCV carriers and chronic hepatitis. 28838891 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression disease BEFREE Active HCV infection is associated with increased circulating levels of interferon-gamma (IFN-γ)-inducible protein-10 (IP-10), soluble CD163 and inflammatory monocytes regardless of liver fibrosis and HIV coinfection. 28578937 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker disease BEFREE Our results indicated significant elevation in IL-10 and IFN-γ in positive hepatitis C patients. 27726476 2017