Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 Biomarker group BEFREE In this study, to directly compare the effect of different mutations in the two HIV-1 CAs on evasion from macaque TRIM5-restriction, we newly generated macaque-tropic HIV-1 (HIV-1mt) proviral clones carrying the distinct CAs in the same genomic backbone, and examined their replication abilities in macaque TRIM5-overexpressing human cells and in rhesus cells. 25195168 2015
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 GeneticVariation group BEFREE Generation of human TRIM5alpha mutants with high HIV-1 restriction activity. 20357830 2010
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 Biomarker group BEFREE Meta-analyses of large cohort studies have identified numerous 'AIDS restriction genes' that regulate HIV cell entry (particularly chemokine coreceptors and their ligands), acquired and innate immunity (major histocompatibility complex, killer cell immunoglobulin-like receptor, and cytokines), and others [tripartite interaction motif 5 alpha (TRIM5alpha) and apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G] that influence outcome of HIV infection. 19317737 2009
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 GeneticVariation group BEFREE The expression of TRIM5 alleles incapable of restricting HIV-1 infection may contribute to the previously reported increased susceptibility of M. nemestrina to HIV-1 infection in vivo. 17804491 2007
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 GeneticVariation group BEFREE Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. 16887163 2006
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 Biomarker group LHGDN HIV-1 infection is restricted more efficiently by rhesus monkey TRIM5alpha than by human TRIM5alpha 14985764 2004
Entrez Id: 85363
Gene Symbol: TRIM5
TRIM5
0.360 Therapeutic group CTD_human The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities. 15249687 2004