The aims of this study were to determine the levels of leptin, C-reactive protein (CRP), and ferritin in relation to volume status and to assess the relationship between leptin and volume and inflammatory status in chronic HD patients.
Multivariable logistic regression analysis showed that leptin (odds ratio [OR] 1.09; 95% confidence interval [CI] 1.04-1.14; p <0.001), diabetes (OR 7.17; CI 1.39-37.00; p = 0.019), body fat mass (OR 1.16; CI 1.02-1.33; p = 0.027); and hemoglobin (OR 2.11; CI 1.15-3.87; p = 0.015) were independently associated with arterial stiffness in HD patients.
Leptin levels and fat-free mass measurements using bioelectric impedance analysis may be good screening tools to identify HD patients at risk for weight loss.
Increased numbers of motor activity peaks during light cycle are associated with reductions in adrenergic alpha(2)-receptor levels in a transgenic Huntington's disease rat model.