Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 GeneticVariation disease BEFREE In order to assess whether single-nucleotide polymorphisms (SNPs) in the OGG1 and XPC genes, both implicated in responses to oxidative stress, are associated with the age of onset of HD, 9 SNPs have been genotyped in 299 individuals with HD and 582 controls. 23830927 2013
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 GeneticVariation disease BEFREE Further analysis showed that combination of MUTYH c.972GG with OGG1 c.977GG or AluYb8MUTYH increased both the risk for ESRD and leukocyte DNA 8-OHdG levels in HD patients. 22720119 2012
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 Biomarker disease BEFREE OGG1 and MSH2/MSH3 promote CAG repeat expansion at Huntington's disease (HD) locusin vivo during removal of oxidized bases from DNA. 21566259 2011
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 Biomarker disease CTD_human In the present study, performed on blood DNA from 91 HD subjects, we observed that bearers of the mutant Cys326 allele (Ser326Cys+Cys326Cys) tend to have an increased number of CAG repeats of the expanded HD allele (P=0.049); moreover bearers of at least one copy of the mutant Cys326 allele, mainly heterozygous subjects, showed a significant (P=0.041) earlier disease onset than Ser326Ser wild-type individuals, suggesting a possible role of the hOGG1 Ser326Cys polymorphism in HD phenotype. 19857538 2010
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 GeneticVariation disease BEFREE In the present study, performed on blood DNA from 91 HD subjects, we observed that bearers of the mutant Cys326 allele (Ser326Cys+Cys326Cys) tend to have an increased number of CAG repeats of the expanded HD allele (P=0.049); moreover bearers of at least one copy of the mutant Cys326 allele, mainly heterozygous subjects, showed a significant (P=0.041) earlier disease onset than Ser326Ser wild-type individuals, suggesting a possible role of the hOGG1 Ser326Cys polymorphism in HD phenotype. 19857538 2010
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 Biomarker disease BEFREE For 215 patients, also information about the first behavioural or cognitive signs of HD was available, so that we also tested for an association with the earliest AO.No association was found with OGG1. 20512606 2010
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.360 GeneticVariation disease BEFREE Here we show that the age-dependent somatic mutation associated with Huntington's disease occurs in the process of removing oxidized base lesions, and is remarkably dependent on a single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase (OGG1). 17450122 2007