Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE This led to metabolic consequences, with significant higher leptin levels and a trend towards hyperinsulinemia, indicating a phenotype resembling the metabolic syndrome. 31398626 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE If leptin and insulin sensitivities increase concurrently, the combined effect could be a decrease in fat mass, consistent with the fact that increasing insulin sensitivity is often associated with fat mass loss in trials. 31626814 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE Subsequently, in vitro studies in 3T3-L1 (white) and T37i (brown) adipocytes suggest that the increased leptin and adiponectin levels were mainly driven by the elevated insulin levels. 31265057 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 PosttranslationalModification disease BEFREE Liver-specific AlbCre+Cc1<sup>fl/fl</sup> mutants exhibited impaired insulin clearance and hyperinsulinemia at 2 months, followed by hepatic insulin resistance (assessed by hyperinsulinemic-euglycemic clamp analysis) and steatohepatitis at ~ 7 months of age, at which point visceral obesity and hyperphagia developed, in parallel to hyperleptinemia and blunted hypothalamic STAT3 phosphorylation in response to an intraperitoneal injection of leptin. 30664851 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE Impaired appetite regulation, in terms of elevated insulin levels and decreased leptin levels, occurs in early psychosis, before antipsychotic treatment. 31121198 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE A constellation of loss of satiety and a reduction of the metabolic rate, thermogenesis, and physical activity as well as increased vagal tone and hyperinsulinism with insulin and leptin resistance results in rapid weight gain due to a decreased energy expenditure and increased energy storage in adipose cells. 30884480 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE Furthermore, hormones that affect energy homeostasis also affect sleep/wake states: the orexigenic hormone ghrelin promotes wakefulness, and the anorexigenic hormones leptin and insulin increase the duration of slow-wave sleep. 30471995 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE This finding together with the positive association of chemerin and leptin with markers of insulin resistance, suggests that these adipokines and more especially chemerin and leptin accompanied by their adipose tissue expression could contribute to the increased insulin resistance and low grade inflammation that characterizes GDM-obese women. 29337272 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE The literature data suggest that chronic hyperinsulinemia increases serum leptin levels in humans and rodents. 29953915 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE Male FATZO mice spontaneously develop significant metabolic disease when compared to normal controls while maintaining hyperglycemia in the presence of high leptin levels and hyperinsulinemia. 28640857 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE The presence of hyperleptinemia without hyperinsulinemia suggests a probable inherent genetic basis for increased leptin resistance in patients with DS. 28749784 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease RGD Creation and preliminary characterization of a leptin knockout rat. 22948215 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 GeneticVariation disease BEFREE Logistic regression analyses showed that factors associated with breast cancer were BMI [OR (95% CI) =2.8 (1.4-5.5), P=0.004]; high levels of adiponectin [5.1 (2.2-11.5), P<0.001); hyperinsulinaemia [1.1 (1.0-1.1), P=0.01], leptin [3.1 (1.7-5.7), P<0.0001], estradiol [2.5 (1.3-4.7), P=0.005] and testosterone [1.3 (1.03-1.7), P=0.03]. 22664497 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE These results identify a novel molecular pathway by which leptin confers inhibitory action on insulin secretion, and impaired PP-1 inhibition by leptin may be involved in dysfunction of the adipoinsular axis during the development of hyperinsulinemia and type 2 diabetes mellitus. 21427225 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE Further, similar hypothalamic leptin transgene expression abrogated chronic hyperglycemia and hyperinsulinemia, the predisposing risk factors of the age and environmentally acquired diabetes type 2, and instituted euglycemia by independently activating relays that stimulate glucose metabolism and repress hyperinsulinemia and improve insulin sensitivity in the periphery. 21209624 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE Analyses of metabolic parameters in maternal venous and umbilical venous plasma revealed significantly increased insulin and leptin as well as slightly increased glucose and TNF-α values in the obese and obese-GDM groups. 21852675 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE In first-degree relatives normal glucose tolerant women, fasting hyperinsulinemia, independently of the presence of metabolic syndrome, is associated with elevated IL-6 and leptin levels, suggesting an increased cardiovascular risk. 19685554 2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE Further, we document here the efficacy of leptin replenishment in vivo, especially by supplying it to the hypothalamus with the aid of gene therapy, in preventing the antecedent pathophysiological sequalae--hyperinsulinemia, insulin resistance and hyperglycemia--in various animal models and clinical paradigms of diabetes type 1 and 2 with or without attendant obesity. 19647774 2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE In summary, our data suggest that hyperinsulinemia could induce breast cancer progression through leptin-dependent mechanisms. 18559540 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease LHGDN Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers. 18404969 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE Notably, the greatest leptin mRNA and protein expression were observed under combined hyperinsulinemia and hypoxia or hypoxia-mimetic treatments. 17653093 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 GeneticVariation disease LHGDN Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. 15533361 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 Biomarker disease BEFREE This study demonstrates that targeted POMC gene delivery in the hypothalamus suppresses food intake and weight gain and reduces visceral adiposity and hyperinsulinemia in leptin-resistant obese Zucker rats. 12882910 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease BEFREE For both genotypes, overweight patients had significantly more steatosis and increased insulin and leptin levels. 14642624 2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.700 AlteredExpression disease LHGDN Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. 12690082 2003