Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.320 Biomarker phenotype CTD_human We previously reported the suppressive effect of cinacalcet on PTH secretion in vivo in a PHPT model mouse, in which parathyroid-targeted overexpression of the cyclin D1 oncogene caused chronic biochemical hyperparathyroidism and parathyroid cell hyperplasia. 21541686 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.320 Biomarker phenotype CTD_human Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis. 20172950 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.320 Biomarker phenotype LHGDN Our findings suggest that TGF-beta1 may act in an autocrine fashion to induce ASM hyperplasia, mediated by its receptor and several kinases including PI3K, ERK, and JNK, whereas p38 MAPK is a negative regulator. 17468136 2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.320 AlteredExpression phenotype LHGDN We expressed cyclin D1 in the beta-cells of mice and islet hyperplasia developed in a time-dependent manner. 15734847 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.320 Biomarker phenotype LHGDN Fistula stenosis is histologically characterized by intimal hyperplasia, which is induced by growth factors, among which transforming growth factor beta1 (TGF-beta1) is of major importance. 12911563 2003
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.320 AlteredExpression phenotype LHGDN Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. 12607604 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.320 Biomarker phenotype CTD_human Cyclin D1 overexpression was observed in 26 of 47 (55%) PN hyperplasias, 3 of 4 (75%) papillomas, and 10 of 18 (56%) TCCs. 12151359 2002
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.310 Biomarker phenotype CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.310 Biomarker phenotype CTD_human Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model. 22561872 2012
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.310 Biomarker phenotype CTD_human Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. 20526721 2010
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.310 Biomarker phenotype CTD_human Taken together, our data indicate that Paneth cell hyperplasia and expression of their various antimicrobial products contribute to the immune response driven by TH2 cytokines, such as IL-9 and IL-13 in the intestinal mucosa. 19342650 2009
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.310 Biomarker phenotype CTD_human Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. 19336973 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.310 Therapeutic phenotype CTD_human Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia. 19234301 2009
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.310 Biomarker phenotype LHGDN Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation. 18204280 2008
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
0.310 GeneticVariation phenotype LHGDN Concordant loss of heterozygosity of DNA repair gene, hOGG1, in melanoma in situ and atypical melanocytic hyperplasia. 18312439 2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.310 AlteredExpression phenotype LHGDN By induction of hypoxia, the cell cycle was dramatically blocked in G1/S phase, and the expression of HIF-1alpha also increased Therefore, sustained expression of HIF-1alpha can inhibit cell hyperplasia, and the apoptosis promotion of injured cells as well as provide protection of endothelial cells. 17473988 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.310 AlteredExpression phenotype LHGDN We investigated whether COX-2 overexpression in atypical hyperplasia is associated with the risk of subsequent breast cancer. 18334709 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.310 Biomarker phenotype CTD_human Cyclooxygenase-2 (COX-2) causes hyperplasia in bladder cells and is considered a key biomarker in bladder cancer. 17093206 2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.310 Biomarker phenotype LHGDN These results support a role of early thrombolysis induced by CO in HO-1-mediated protection against intimal hyperplasia after vascular injury. 16783602 2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.310 AlteredExpression phenotype LHGDN Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. 16009333 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.310 Biomarker phenotype LHGDN MMP-9 not only participates in the degradation of elastic tissue but also is associated with intimal hyperplasia, subsequent luminal narrowing, and neoangiogenesis. 15998676 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.310 Biomarker phenotype CTD_human Increased matrix metalloproteinase-9 (MMP-9) expression is associated with intimal hyperplasia in saphenous vein (SV) bypass grafts. 15728660 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.310 Biomarker phenotype CTD_human As a molecular marker of oxidative stress, increased COX-2 expression was noted in 17 of 18 (94%) TCCs, 4 of 4 (100%) papillomas, and 39 of 47 (83%) PN hyperplasias. 12151359 2002
Entrez Id: 442908
Gene Symbol: MIR340
MIR340
0.300 Biomarker phenotype CTD_human mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice. 25926378 2016
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.300 Biomarker phenotype CTD_human Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues. 25481498 2015