Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group BEFREE We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA). 31805646 2019
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE Our findings indicate that the α-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians. 30552709 2019
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE This study examined the SNPs AGT rs699 (Met235Thr), ADD1 rs4961 (rs4961" genes_norm="118">Gly460Trp), NPPA rs5063 (Val32Met), GPX1 rs1050450 (Pro198Leu), and AGTR1 rs5186 (A1166C) in relation to hypertension and salt sensitivity. 27480094 2017
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The results showed that Chinese with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1.28; 95%CI, 1.09-1.51; P = 0.003). 28040068 2016
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 AlteredExpression group BEFREE The specific function of DNA methylation in regulating the expression of AH-related genes at promoter site was described for hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), somatic angiotensin converting enzyme (sACE), Na+/K+/2Cl- cotransporter 1 (NKCC1), angiotensinogen (AGT), α-adducin (ADD1), and for other crucial genes in endocrine hypertension. 25035152 2015
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group BEFREE Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis. 26042478 2015
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37). 24271554 2014
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group BEFREE Hypertension is closely linked to ischaemic stroke (IS) and atherosclerosis, but there are no studies correlating the candidate hypertensive gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with magnetic resonance angiographic (MRA) abnormality, therefore this study was undertaken. 23540412 2013
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group BEFREE Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. 23509723 2013
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE Computational study of ADD1 gene polymorphism associated with hypertension. 22810272 2013
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese. 21364877 2011
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group BEFREE Further studies investigating gene-gene, gene-environment and mutual interactions are needed to better understand the role of ADD1 in hypertension. 21228790 2011
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE Our case-control study and the following meta-analysis failed to provide evidence for the genetic association of alpha-adducin gene G460W polymorphism with hypertension. 19960031 2010
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension. 20927398 2010
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension. 20145305 2010
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the Adducin-1 (ADD1) G460W nonsense single nucleotide polymorphism (SNP) have previously been associated to hypertension, whereas their association with preeclampsia (PE) and gestational hypertension (GH) is still controversial. 19443911 2009
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 Biomarker group CTD_human [Association of the polymorphisms of sodium transport related genes with essential hypertension]. 19199261 2009
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension. 19145769 2009
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE We studied the risk of stroke, coronary heart disease (CHD), and myocardial infarction (MI) associated with the alpha-adducin variant and examined the extent to which this risk is modified by the presence of hypertension. 18458162 2008
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group LHGDN Genetic variation in alpha-adducin cytoskeletal protein is implicated in the polymerization and bundling of actin and alteration of the Na/K pump, resulting in abnormal renal sodium transport and hypertension in Milan hypertensive rats and humans. 18524856 2008
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells. 18667944 2008
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group LHGDN The alpha-adducin gene TT and ACE II genotypes might be genetic susceptibility factors to hypertension accompanying renal injury. 18393230 2008
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists. 18657677 2008
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group BEFREE The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension. 17984662 2007
Entrez Id: 118
Gene Symbol: ADD1
ADD1
0.600 GeneticVariation group LHGDN The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension. 17984662 2007