Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature. 31836539 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE This study measured stimulus-evoked brain tissue oxygenation changes in a mouse model of Alzheimer disease (AD) and further explored the influence of exercise and angiotensin II-induced hypertension on these changes. in vivo two-photon phosphorescence lifetime microscopy was used to investigate local changes in brain tissue oxygenation following whisker stimulation. 31726177 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Histone deacetylase inhibitor CG200745 ameliorates high-fat diet-induced hypertension via inhibition of angiotensin II production. 31655853 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE During type 2 diabetes (T2D) and hypertension there is stimulation of renal proximal tubule angiotensinogen (AGT), but whether urinary excretion of AGT (uAGT) is an indicator of glomerular damage or intrarenal RAS activation is unclear. 31761419 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression group BEFREE Down-regulation of Brain Gα12 attenuates Angiotensin II Dependent Hypertension. 31677381 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks. 31790054 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE However, the role of ICAM-1 in angiotensin II (Ang II)-induced hypertension development remains unknown. 31527830 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation group BEFREE Female rats harboring the human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype with hypertension and albuminuria during pregnancy when mated with male rats bearing the human renin gene [TGR(hRen)L10J] but behave physiologically normal before and after pregnancy. 31786987 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Utilizing our genetic mouse model of inducible renal lymphangiogenesis, we demonstrated that greatly augmenting renal lymphatic density prior to angiotensin II infusion prevented the development of hypertension in male and female mice and this was associated with a reduction in renal CD11c+F4/80- monocytes. 31429865 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Renal proximal tubular angiotensinogen (AGT) is increased by hyperglycemia (HG) in diabetes mellitus, which augments intrarenal angiotensin II formation, contributing to the development of hypertension and kidney injury. 31682172 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression group BEFREE Higher AGT levels in serum and urine in children with renal cysts may indicate the activation of the renin-angiotensin-aldosterone system, including its intrarenal part, even before the onset of hypertension. 31379247 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE We generated a <i>Gstm1</i> knockout mouse line to study its role in a CKD model (involving subtotal nephrectomy) and a hypertension model (induced by angiotensin II). 31727850 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Blockade of Angiotensin-Converting Enzyme or TNF-α Reverses Maternal High Fat Diet-Induced Sensitization of Angiotensin II Hypertension in Male Rat Offspring. 31746626 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Treatment with the cathepsin L inhibitor Z-FF-FMK or the genetic deletion of cathepsin L significantly attenuated angiotensin II-induced hypertension, arterial remodeling, cathepsin L activation and MEK phosphorylation. 31668507 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Angiotensin II receptor blockers (ARBs) are recommended for treating patients with hypertension. 30964905 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation group BEFREE So, the aim of current study was to develop efficient low-cost method for genotyping of cardiovascular disease and hypertension associated polymorphisms of AGT (rs4762, rs5051) and CYP11B1 (rs6410). 30478747 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Our results show that NRP1 is required for full expression of DDAH1 in endothelial cells and that NRP1 contributes to protection from low-dose angiotensin II-induced increases in blood pressure.-Wang, Y., Wang, E., Zhang, Y., Madamsetty, V. S., Ji, B., Radisky, D. C., Grande, J. P., Misra, S., Mukhopadhyay, D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension. 30118322 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Finally, administration of neutralizing PDGF-C antibodies ameliorated angiotensin II-induced hypertension in healthy mice. 30827511 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Angiotensin II-induced hypertension increases the mutant frequency in rat kidney. 31098697 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE We tested the hypothesis that SGLT2 inhibition with canagliflozin (CANA) prevents intrarenal AGT augmentation and ameliorates kidney injury and hypertension in T2DM. 30921791 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Telmisartan, an angiotensin II receptor blocker, has been widely used for hypertension. 30907023 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Therefore, ACE could be a potential therapeutic target in regulating the conversion of angiotensin I to angiotensin II and eventually controlling hypertension. 30875817 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. 30580687 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation group BEFREE The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR). 31037948 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker group BEFREE It was hypothesized that in vivo, functional deletion of Ca<sub>v</sub>3.1, but not Ca<sub>v</sub>3.2, protects mice against angiotensin II (ANG II)-induced hypertension. 31042060 2019