| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.630 | GeneticVariation | group | BEFREE | Recent studies have demonstrated that two genetic variants of ECE1 gene, rs212528 and rs213045 (C338A), are associated with hypertension and atherosclerosis formation. | 24595843 | 2014 | ||||
|
0.630 | AlteredExpression | group | BEFREE | Up-regulation of ECE-1 could contribute, at least partially, to the development of hypertension seen in apoE mice, because FR-901533 avoided it. | 18997155 | 2009 | ||||
|
0.630 | GeneticVariation | group | LHGDN | We genotyped 5 single nucleotide polymorphisms (SNPs) in the ECE1 gene in 1,873 individuals from a general Japanese population and identified one SNP associated with hypertension in women (rs212528: TT vs. TC+CC: odds ratio=1.40; 95% confidence intervals: 1.04-1.89; p=0.026), after adjusting for confounding factors. | 17664854 | 2007 | ||||
|
0.630 | GeneticVariation | group | BEFREE | We genotyped 5 single nucleotide polymorphisms (SNPs) in the ECE1 gene in 1,873 individuals from a general Japanese population and identified one SNP associated with hypertension in women (rs212528: TT vs. TC+CC: odds ratio=1.40; 95% confidence intervals: 1.04-1.89; p=0.026), after adjusting for confounding factors. | 17664854 | 2007 | ||||
|
0.630 | Biomarker | group | CTD_human | Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation. | 12566389 | 2003 | ||||
|
0.630 | Biomarker | group | RGD | Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats. | 12193123 | 2002 | ||||
|
0.630 | Biomarker | group | RGD | Increased renal medullary endothelin-1 synthesis in prehypertensive DOCA- and salt-treated rats. | 10894793 | 2000 | ||||
|
0.630 | Biomarker | group | HPO |