Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Taken together, our study indicates that Smad2/3/SphK1/S1P/Notch3 pathway mediates TGF-β1-induced PASMC proliferation and suggests this pathway as a potential therapeutic target in the prevention and treatment of pulmonary hypertension. 30430898 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE We found that OSA combined with HSD increased the severity of hypertension through increasing level of blood Trimethylamine-Oxide (TMAO), release of Th1-related cytokine (IFN-γ) and inhibition of anti-inflammatory cytokine (TGF-β1), and affected the gut microbiome in rats, particularly by depleting Lactobacillus. 30784906 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats. 31254954 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE The expression of TGF-β1 was significantly elevated, whereas the expression of PI3KC3 was significantly downregulated in the patients with hypertension compared with controls. 30783440 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE MiR-21 regulates pulmonary hypertension in rats via TGF-β1/Smad2 signaling pathway. 31115027 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension. 29976656 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE It was concluded that the the MRs-redox signalling pathway is involved in TGF-β1-induced renal tubular EMT and renal inflammation/fibrosis in AngII-induced hypertension. 29863758 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Transforming growth factor‑β1 (TGF‑β1)/small mothers against decapentaplegic 3 (Smad3) is considered a potential therapeutic target for vascular remodeling in hypertension. 28791353 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Heart tissue was analyzed by histopathological morphometry, including assessments of ventricular and coronary vascular hypertrophy and fibrosis, as well as immunohistochemistry analyses of myocardial expression of AT<sub>1</sub>R. l-NAME treatment reduced the plasma nitrate level and led to the development of hypertension, with increased plasma levels of AT II and increased heart transcriptional levels of AT<sub>1</sub>R and TGF-β1-mediated connective tissue proteins, showing myocardial and coronary arteriolar hypertrophy and fibrosis. 28438687 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE The present study tested the hypothesis whether elevated TGF-β1 levels can predict the development of hypertension. 28575138 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE GSPE decreased oxidative stress associated with hypertension in SHR and suppressed the increased expression of TGF‑β1, which blocked the translocation and differentiation of adventitia fibroblasts and eventually inhibited collagen hyperplasia in the blood vessel. 28447711 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways. 27297622 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE TGFB1 rs1800469 polymorphism was observed to be associated with IA through co-modifying factors such as hypertension and gender. 26198819 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE Hypertension was associated with the CC genotype and C allele for IL-10 -592C/A polymorphism (p = 0.013 and p = 0.009) and higher frequencies of T (p = 0.047) and C (p = 0.033) alleles of the TGF-β1 codon 10T/C and IL-10 -819T/C polymorphisms, respectively. 26064986 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE We assessed the association between 5 well-defined polymorphisms of the transforming growth factor-β1 (TGFB1) gene and coronary artery disease (CAD) among patients with hypertension from northeast China. 25155040 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1, and VCAM1 and decreased expression of SELPLG and SERPINEB2. 23337395 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Normally distributed square root of TGF-β1 (pg/ml) of hypertension cases (148.56 ± 66.46) was significantly higher than that of control (128.52 ± 65.11), P = 0.008. 24413999 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE Conversely, P311-transgenic (P311(TG)) mice had elevated levels of TGF-β1-TGF-β3 and subsequent hypertension. 24091331 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE In this study, the authors performed a meta-analysis to investigate the associations of +869T/C and +915G/C polymorphisms in TGF-β1 gene with hypertension risk in Chinese. 22209986 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group BEFREE TNF-α neutralization reduced hypertension, albuminuria and renal inflammation and fibrosis, which were coupled to a reduction in renal NF-ĸB activation, inflammatory markers expression, TGF-β1 and ET-1 production, and an increase in NO release. 22813949 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE Our data provide evidence that calpain mediates EGF- and PDGF-induced collagen synthesis and proliferation of pulmonary artery smooth muscle cells via an intracrine TGF-β1 pathway in pulmonary hypertension. 22005303 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group BEFREE TGF-beta(1) may cause endothelial dysfunction in apolipoprotein E-deficient (apoE(-/-)) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart remodeling and hypertension. 20511416 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 GeneticVariation group BEFREE In some, but not all, studies, IL6 -174G/C (rs1800795) and TGFB1 869T/C (rs1982073) gene polymorphisms have been associated with hypertension in the general population. 19106168 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 Biomarker group CTD_human Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways. 19018797 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.600 AlteredExpression group LHGDN Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome. 18097622 2008