Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 Biomarker group BEFREE These results show that PTPN22 promotes intestinal inflammation in IL-10-deficient mice, suggesting that therapeutic targeting of PTPN22 might be beneficial in patients with IBD and mutations in IL-10 and IL-10R. 31194881 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 Biomarker group BEFREE While the role of PTPN22 in modulating molecular pathways involved in IBD pathogenesis is well studied, its impact on shaping the intestinal microbiota has not been addressed in depth. 31107248 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE Here, we investigated the influence of PTPN2 and PTPN22 gene variants on intestinal microbiota composition in IBD patients. 29965986 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 AlteredExpression group BEFREE Furthermore, association between inflammation and decreased expression levels of MAGI3, PTEN, and TJP1 in colonic IBD as well as UC mucosa, and between inflammation and increased expression of PTPN22 in colonic IBD mucosa, was observed. 28545409 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE Conversely, patients with inflammatory bowel disease (IBD) that carried an autoimmunity-associated PTPN22 variant had increased IL-1β levels. 27043286 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE Our study for the first time addressed how presence of SNP rs2476601 within the PTPN22 gene affects clinical characteristics in IBD-patients. 27467733 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD. 24971461 2014
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 AlteredExpression group BEFREE Intestinal tissue samples from patients with or without inflammatory bowel disease (controls) were analyzed for levels of PTPN22 messenger RNA (mRNA) and protein. 23380085 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE Our data demonstrate that PTPN22 controls NOD2 signaling, and loss of PTPN22 renders monocytes more reactive towards bacterial products, what might explain the association of PTPN22 variants with IBD pathogenesis. 23991106 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 Biomarker group CTD_human Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. 21983784 2011
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE These observations confirm the association of IBD susceptibility with the PTPN22 1858T (620-W) allele in Tunisian patients. 20101775 2010
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE This meta-analysis showed the association between the T-allele and the T/T genotype and JIA (OR = 1.34, P = 0.03; OR = 1.97, P = 0.02) but did not reveal the association between the PTPN22 C1858T polymorphism and IBD, psoriasis, multiple sclerosis, Addison's disease and Celiac disease. 16760194 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE Although involved in autoimmune diseases, the PTPN22 and NFkB1 genes do not seem involved in the IBD predisposition, also according to meta-analysis results. 17600378 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.400 GeneticVariation group BEFREE These results indicate that the PTPN22 1858C-->T polymorphism does not appear to play a major role in IBD predisposition in our population. 16185327 2005