Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE The gist of current study is to assess the role of IBD-associated autophagy gene IRGM on AS susceptibility in a Chinese Han population. 28031552 2017
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE We analyzed known autophagic loci (IRGM, ULK1 and AMBRA1) previously described as associated with inflammatory bowel diseases or with other autoimmune and/or inflammatory disorders in a sample of Italian inflammatory bowel diseases patients in order to confirm their possible involvement and relative contribution in the disease. 26066377 2015
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group CTD_human Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE This study examined the association of IRGM mutations with ulcerative colitis and Crohn's disease in Indian patients with inflammatory bowel disease. 25191865 2014
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE IRGM variants and susceptibility to inflammatory bowel disease in the German population. 23365659 2013
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE Polymorphisms in immunity-related GTPase family M (IRGM) gene may be associated with inflammatory bowel disease (IBD) by affecting autophagy. 24232856 2013
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population. 22508677 2013
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group GWASDB Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group GWASCAT Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE The discovery that several genes linked to IBD modulate microbial recognition and innate immune pathways, such as nucleotide oligomerization domain 2 (Nod2), and genes that mediate autophagy (ie, ATG16L1, IRGM), has highlighted the critical role of host-microbe interactions in controlling intestinal immune homeostasis. 22955361 2012
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE We analysed five variants (rs10758669 within JAK2, rs744166 within STAT3, rs4958847, rs11747270 and rs13361189 within IRGM) in adult German inflammatory bowel disease patients (CD, n = 464; ulcerative colitis (UC), n = 292) and matched healthy controls (n = 508). 22065112 2012
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE The discovery of the autophagy genes ATG16L1 and IRGM as risk factors for Crohn's disease turned autophagy into the spotlight in inflammatory bowel disease (IBD). 21252204 2011
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE We reexamined these findings as well as the role of another inflammatory bowel disease (IBD) susceptibility gene (immunity-related GTPase family, M [IRGM]) on transplantation outcomes in 390 US patients and their matched unrelated donors, accrued between 1995 and 2004. 20177049 2010
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE Based on this idea, NKX2-3, ATG16L1, and IRGM which are well-established inflammatory bowel disease risk factors, could be new celiac disease (CD) candidate genes. 19683022 2009
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 GeneticVariation group BEFREE Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. 19491842 2009
Entrez Id: 345611
Gene Symbol: IRGM
IRGM
0.500 Biomarker group BEFREE Genome scans have robustly identified 11 susceptibility genes and loci and highlighted a number of new, previously unsuspected pathways as playing an important role in IBD pathogenesis-including the IL23 pathway in IBD overall and specific aspects of innate immunity (particularly NOD2 and the autophagy genes ATG16L1 and IRGM) in CD. 18753178 2008