Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE One of those four patients was homozygous for the ATG16L1 Crohn's disease-associated gene variant but had no history of inflammatory bowel disease. 31692018 2020
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE SNPs rs1800896, rs3024505 (IL-10); rs11209026 (IL23R); rs2066844, rs2066845 (NOD-2), and rs2241880 (ATG16L1) were assessed in 93 patients with IBD and 200 healthy controls by hybridization probes and quantitative PCR. 31651650 2020
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE <b>Abbreviations:</b> ATG16L1: autophagy-related 16-like 1 (S. cerevisiae); DAMP: damage-associated molecular pattern; HBSS: Hanks balanced salt solution; HMGB1: high mobility group box 1; IBD: inflammatory bowel disease; IL1B/Il-1β: interleukin 1 beta; IL10: interleukin 10; IL17/IL-17: interleukin 17; MEFs: mouse embryonic fibroblasts; STAT3: signal transducer and activator of transcription 3; TLR: toll-like receptor; TNF/TNF-α: tumor necrosis factor. 30894054 2019
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE Loss of A20 and Atg16l1 in mouse intestinal epithelium induces spontaneous IBD-like pathology, as characterized by severe inflammation and increased intestinal epithelial cell death in both small and large intestine. 31015422 2019
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE We evaluated the impact of variations in ATG16L1 and NOD2 and genes on serologic responses in patients with inflammatory bowel disease (IBD). 30265311 2019
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE These findings suggest that the IBD susceptibility gene ATG16L1 and the process of autophagy within the epithelium control inflammation-induced apoptosis and barrier integrity to limit chronic intestinal inflammation. 29358084 2018
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Cells harbouring the ATG16L1 T300A allele associated with inflammatory bowel disease were also found to accumulate cholesterol and be defective in repair, linking a common inflammatory disease to plasma membrane integrity. 30478389 2018
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE We evaluated the association of several single nucleotide polymorphisms (SNPs) in the autophagy related 16 like 1 (ATG16L1) gene with IBD in Indians. 28542425 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE The autophagy-related 16-like 1 gene (Atg16l1) is associated with inflammatory bowel disease (IBD) and has been shown to play an essential role in paneth cell function and intestinal homeostasis. 28390705 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE Furthermore, TMAO-mediated effects were observably reversed by over-expression ATG16L1 and siRNA-mediated knockdown NLRP3.The present results support the hypothesis that TMAO may be involved in the pathogenesis of IBD by impacting ATG16L1-induced autophagy and activating NLRP3 inflammasome, suggesting a potential therapeutic targets for the treatment of IBD and TMAO-associated complications. 28629999 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE We demonstrate that ATG16L1 in the intestinal epithelium is essential for preventing loss of Paneth cells and exaggerated cell death in animal models of virally triggered IBD and allogeneic hematopoietic stem cell transplantation. 29089374 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Genetic polymorphisms in the known IBD-associated gene ATG16L1 correlate with requirement of treatment, suggesting a different IBD disease phenotype in these patients. 29228965 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group CTD_human Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE The discovery that several genes linked to IBD modulate microbial recognition and innate immune pathways, such as nucleotide oligomerization domain 2 (Nod2), and genes that mediate autophagy (ie, ATG16L1, IRGM), has highlighted the critical role of host-microbe interactions in controlling intestinal immune homeostasis. 22955361 2012
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Actively inflamed intestinal biopsies from CD patients carrying either ATG16L1 or PTPN2 genetic variants revealed aberrant LC3B expression patterns when compared with samples from non-IBD control patients. 21987459 2012
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 Biomarker group BEFREE The recent findings in IBD include the increasing number of IBD susceptibility genes, the demonstration that NOD2 and ATG16L1 are linked in one functional pathway and the role of IL-33/ST2 in colitis. 21099431 2011
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE The discovery of the autophagy genes ATG16L1 and IRGM as risk factors for Crohn's disease turned autophagy into the spotlight in inflammatory bowel disease (IBD). 21252204 2011
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Neither the other two NOD2 variants, nor the known variants in IL23R and ATG16L1 were found to be risk factors for CD, UC or IBD. 20082483 2010
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE The propensity to develop IBD has not been linked to single gene mutations in most instances, but has been linked to SNP in the NOD2 locus (which appear to create hypomorphic alleles for this bacterial response gene), the IL23R locus, the autophagy gene ATG16L1 and a wide range of other loci including the Toll-like receptors, JAK2 and STAT3, and perhaps 70 more. 21088407 2010
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD. 20222171 2010
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE To establish the relevance of variants in the IL-23R and ATG16L1 genes in inflammatory bowel disease (IBD). 19276991 2009
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Therefore we aimed to replicate these novel CD susceptibility variants in a large European cohort with inflammatory bowel disease and analyzed potential gene-gene interactions with variants in the NOD2/CARD15, IL23R, and ATG16L1 genes. 19262523 2009
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.500 GeneticVariation group BEFREE Our aims were: to replicate the ATG16L1 Thr300Ala association with inflammatory bowel disease (IBD) in the Spanish population, to perform a meta-analysis to determine the risk conferred to the different IBD subgroups, and to test for the interaction with CARD15 or IL23R risk loci. 19575361 2009