Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE The apolipoprotein A-I (APOA1) mimetic 4F mitigated disease in both the Cox2 MKO/CCHF and piroxicam-accelerated Il10-/- models of inflammatory bowel disease (IBD) and reduced elevated levels of pro-inflammatory mediators in tissue and plasma. 31184596 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Cyclooxygenase-2 (COX-2) has long been implicated in the pathogenesis of inflammatory bowel diseases (IBDs). 29630407 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE COX-2 mRNA levels increased similarly with statistical significance in IBD and CRC. 30186819 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE The present study aimed to determine the mRNA levels of MDR1 and COX2 in cats with IBD and LGAL, and to evaluate their correlation with clinical signs, histological severity and between genes. 28948903 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Canonical NF-κB pathway activation is well studied in IBD and is associated with the rapid, acute production of diverse proinflammatory mediators, such as COX-2, IL-1β, and IL-6. 27508514 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE In this study, we elucidated the anti-inflammatory effect of YPFS that is mediated through modulating the expression of three key enzymes involved in IBD: inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and intestinal alkaline phosphatase (IALP). 24967898 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE Carriers of the COX-2 A-1195G variant allele had increased risk of UC (odds ratio [OR], 95% confidence interval [CI] = 1.25 [1.02-1.54], P = 0.03) and of both UC and IBD among never smokers (OR [95% CI] = 1.47 [1.11-1.96], P = 0.01 and OR [95% CI] = 1.37 [1.06-1.77], P = 0.02, respectively). 20803508 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Our observations suggest that the inhibition of P-gp by COX-2-inhibitors could contribute to the improvement of medical response and this finding may have relevance to medical treatment of inflammatory bowel disease patients. 20361960 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE The aim of this study was to investigate the possible modulating effect of the functional COX-2 polymorphisms -1195 A→G and -765G→C on the risk for development of inflammatory bowel disease (IBD) in a Dutch population. 21124790 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. 18819034 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Because TNF-alpha and COX-2 are increased in patients with inflammatory bowel disease (IBD), we investigated the role of SK1 in a murine model of colitis. 18815359 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Moreover, curcumin inhibits microvascular endothelial cell angiogenesis through inhibition of COX-2 expression and PGE(2) production, suggesting that this natural product possesses antiangiogenic properties, which warrants further investigation as adjuvant treatment of IBD and cancer. 18596194 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE Polymorphisms in the PTGS2 gene have been associated with various diseases, including inflammatory bowel disease and cancer of the lung, colorectum, and breast. 17214885 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE We have genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene. 16273614 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Over the years, the study of exfoliated colonocytes has provided striking new insights into the biology of colon cancer and inflammatory bowel disease, including detection of p53 gene mutations, reverse transcriptase polymerase chain reaction amplification, and identification of CD44 splice variants, neoplasia-associated specific binding of plant lectins, and expression of COX-2, the inducible form of cyclooxygenase. 12702972 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Preliminary observations on COX-2 expression in inflammatory bowel disease (IBD)-related colorectal neoplasia are also presented. 12494894 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human In inflammatory bowel disease, increased production of prostaglandins by cyclooxygenase-2 (COX-2) contributes to bowel dysfunction, inflammatory edema, and hyperemia suggesting that inhibitors of COX-2 may have beneficial effect in gut inflammation. 11820457 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE The expression and cellular localization of COX-1 and COX-2 in normal human colon and inflammatory bowel disease (IBD) surgical resections were studied. 9679035 1998