Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Tumour necrosis factor α inhibitors (anti-TNFα) are the main therapy for moderate to severe inflammatory bowel disease (IBD) in children. 31535405 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Treatment with tumor necrosis factor antagonists increased steadily for patients with CD (43.4% of all patients in Brazil were treated in 2014) but less so for patients with UC (4.5% of all patients were treated in 2014).Surgery for IBD decreased with time. 31252191 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 GeneticVariation group BEFREE A total of 2701 IBD patients under current or former treatment with TNF-α inhibitors were identified in an IBD registry covering the period 1994-2018. 31466830 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Effects of Tumor Necrosis Factor Alpha Inhibitors on Lymph Node and Ileocecal Mucosa-Associated Lymphoid Tissue Architecture in Patients With Inflammatory Bowel Disease. 31362580 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE A Population-Based Study of Combination vs Monotherapy of Anti-TNF in Persons With IBD. 31340002 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Adequate serum drug levels of tumor necrosis factor-alpha inhibitors (anti-TNF) have been shown to improve outcomes in patients with inflammatory bowel disease (IBD). 31503216 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Combination therapies for IBD that include TNF antagonists, especially with corticosteroids, are associated with a higher risk of serious infection, whereas monotherapy with an immunosuppressive agent is associated with a lower risk, compared with monotherapy with a TNF antagonist. 30876964 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Trends of Utilization of Tumor Necrosis Factor Antagonists in Children With Inflammatory Bowel Disease: A Canadian Population-Based Study. 31323083 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Human genetic, tissue expression, proteomics, transcriptomics, and nonclinical studies implicate tumor necrosis factor α-like ligand 1A (TL1A) as a novel target in inflammatory bowel disease (IBD). 31758576 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Tumor necrosis factor (TNF)-α is a major proinflammatory cytokine that plays a key role in inflammatory bowel disease (IBD). 31586441 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE The efficacy of antitumour necrosis factor (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation and perpetuation of IBD. 30407662 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE There was a positive correlation between IgA and IgG on CD but not UC, as well as between IgA and TNF in total IBD patients. 30884988 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Is There a Risk of Lymphoma Associated With Anti-tumor Necrosis Factor Drugs in Patients With Inflammatory Bowel Disease? A Systematic Review of Observational Studies. 30941038 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE In recent years, more molecules, both biologically and chemically synthetized, have been developed as potential therapeutic options for IBD that target different molecular pathways aside from TNF blockade, and which have been proposed as targets for novel drugs. 31316377 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Anti-tumor necrosis factor-alpha (anti-TNF-α) therapy alters the gut microbiota in many diseases, including inflammatory bowel disease. 31556231 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE We therefore performed a comprehensive analysis of vedolizumab-induced alterations in mucosal and systemic immunity in patients with inflammatory bowel disease (IBD), using anti-inflammatory therapy with the TNFα antibody infliximab as control. 29730603 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. 31358760 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Sex Differences in Response to TNF-Inhibiting Drugs in Patients With Spondyloarthropathies or Inflammatory Bowel Diseases. 30745872 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Corticosteroids and Thiopurines, But Not Tumor Necrosis Factor Antagonists, are Associated With Cytomegalovirus Reactivation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. 27875356 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Since production of TNFα is a feature of IBD relevant to therapies, we sought to determine whether B cells in GALT or the CD27<sup>-</sup>IgD<sup>-</sup> subset in particular could contribute to pathology by secretion of TNFα or IL-10. 30891036 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease. 30811631 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE We performed a systematic review of changes in fecal and colon microbiomes of patients with inflammatory bowel diseases (IBD) receiving treatment with monoclonal antibodies against tumor necrosis factor (TNF), integrins, or cytokines. 31526845 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE The clinical success of biologics that inhibit TNF (Tumor Necrosis Factor) in inflammatory bowel diseases (IBD), psoriasis and rheumatoid arthritis (RA) has clearly established a pathogenic role for this cytokine in these inflammatory disorders. 31457011 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Tumor necrosis factor alpha (TNF-α) is usually regarded as a potential target for inflammatory bowel disease therapy. 30714345 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.600 Biomarker group BEFREE Although KEGG showed inflammatory bowel disease in the E. coli group, the KEGG pathway analysis showed that these DEGs were mainly involved in the tumor necrosis factor signaling pathway, fructose metabolism, and mannose metabolism in both <i>S. aureus</i>- and <i>E. coli</i>-induced sepsis. 31093495 2019