Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE In this chapter, we summarize the clinical, neuropathologic, biochemical, and diagnostic features of dura mater graft- and human pituitary-derived growth hormone-associated CJD patients for the appropriate diagnosis of iatrogenic CJD. 29887137 2018
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE The identification of Creutzfeldt-Jacob disease in individuals who received pituitary-derived GH led to heightened surveillance for safety issues related to recombinant human GH (rhGH). 30378793 2018
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Based on extensive modelling of human prion transmission barriers in transgenic mice expressing human prion protein on a mouse prion protein null background, the temporal distribution of codon 129 genotypes within the cohort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there was a point source of infecting prion contamination of growth hormone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valine 129. 26268531 2015
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone. 26108478 2015
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment, typically in childhood, with human cadaveric pituitary-derived growth hormone contaminated with prions. 26354483 2015
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Among the cases of iatrogenic CJD, 13 cases of CJD after duramater grafts were observed and 119 related to treatment with growth hormone. 23587616 2013
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Epidemiological studies on human transmissible spongiform encephalopathies (Creutzfeldt-Jakob Disease, CJD) have shown that the agent could be transmitted by highly infectious tissues like brain, spinal cord or retina and medicinal products derived from these tissues (i.e. human growth hormone, dura mater). 16151959 2005
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 GeneticVariation disease BEFREE Creutzfeldt-Jakob disease in United Kingdom patients treated with human pituitary growth hormone. 14504321 2003
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE Since homozygosity MM at codon 129 of the prion protein gene is a recognised risk factor in all forms of Creutzfeldt-Jakob disease (CJD), we studied the distribution of codon 129 polymorphism in patients in France and in the UK with CJD transmitted iatrogenically by human growth hormone. 12867116 2003
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE The proportion of recipients acquiring CJD from growth hormone varies from 0.3 to 4.4% in different countries, and acquisition from dura mater varies between 0.02 and 0.05% in Japan (where most cases occurred). 11071481 2000
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 GeneticVariation disease BEFREE The most frequent of the latter include acquired forms secondary to injections of human cadaveric pituitary-derived growth hormone and the new variant of CJD--probably related to bovine spongiform encephalopathy. 10221164 1999
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 GeneticVariation disease BEFREE We tested DNA from 15 centrally infected cases of iatrogenic Creutzfeldt-Jakob disease (CJD) (dura mater or corneal homografts and stereotactic EEG electrodes), 11 peripherally infected cases (native human growth hormone or gonadotrophin), and 110 control individuals for the presence of mutations in the chromosome 20 amyloid gene. 8309577 1994
Entrez Id: 2688
Gene Symbol: GH1
GH1
0.100 Biomarker disease BEFREE The spongiform encephalopathy Creutzfeldt-Jakob disease (CJD) has been transmitted to man via administration of growth hormone and gonadotropin extracted from large pooled batches of human cadaveric pituitary glands. 1675319 1991