Gene: CLDN14 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE Intronic mutations in claudin-14 increase expression causing hypercalciuria and kidney stones. 29782346 2018
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 Biomarker disease BEFREE Coupled with mouse experiments, these results support a major role for claudin-14, a gene associated with kidney stones, in the differential paracellular handling of divalent cations by the renal tubule. 27915449 2017
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE Synonymous variants in claudin-14 have been associated with hypercalciuric nephrolithiasis by genome-wide association studies (GWASs). 27878608 2017
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE To test this hypothesis, we sequenced the CLDN14 risk haplotype in a cohort of children with idiopathic hypercalciuria and kidney stones. 28229505 2017
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 Biomarker disease BEFREE A recent genome-wide association study has identified claudin-14 as a major risk gene of hypercalciuric nephrolithiasis. 27191348 2016
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE Genetic mutations in claudin-16 and -19 cause familial hypomagnesemic hypercalciuria with nephrocalcinosis, whereas polymorphisms in claudin-14 are associated with kidney stone risk. 24948743 2015
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 Biomarker disease BEFREE This study aimed to evaluate the association between genetic defects in vitamin D receptor (VDR), calcium sensing receptor (CaSR) and claudin 14 (CLDN14) genes and kidney stone disease in patients from eastern India. 26107257 2015
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease GWASCAT Common and rare variants associated with kidney stones and biochemical traits. 26272126 2015
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 Biomarker disease BEFREE The only high-throughput genome-wide association study identified claudin 14 (CLDN14) gene as a possible major gene of nephrolithiasis. 20962745 2011
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk of kidney stone disease; and variants in or near SHROOM3, STC1, LASS2, GCKR, NAT8/ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, FAM122A/PIP5K1B, ATXN2, DACH1, UBE2Q2/FBXO22, and SLC7A9, with differences in glomerular filtration rate. 20728256 2010
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 Biomarker disease CTD_human We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). 19561606 2009
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease BEFREE We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). 19561606 2009
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease GWASCAT We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). 19561606 2009
Entrez Id: 23562
Gene Symbol: CLDN14
CLDN14 		0.500 GeneticVariation disease GWASDB We discovered common, synonymous variants in the CLDN14 gene that associate with kidney stones (OR = 1.25 and P = 4.0 x 10(-12) for rs219780[C]). 19561606 2009