Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The aim of this study was to investigate the relationship between methylation profile in the MTHFR gene promoter and biochemical, inflammatory and oxidative stress markers in individuals with type 2 diabetes (T2DM) who have been diagnosed for 5-10 years with or without diabetic retinopathy (DR) and nephropathy (DN). 29075332 2017
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE A total of 40 male patients with CKD and stable renal function (Kidney Disease Outcomes Quality Initiative stages 2 and 3) were classified according to MTHFR polymorphism as carrier T(+) or non carrier T(-). 24711158 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes. 21613384 2012
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE MTHFR C677T and A1298C polymorphisms were not associated with the presence of renal disease. 19376104 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 Biomarker group CTD_human Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. 18551038 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE To support our suggestion, we examined in detail the association of MTHFR polymorphism with diabetic retinopathy and nephropathy in Japanese type 2 diabetic patients. 18280442 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy. 18774994 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The MTHFR genotype and allele frequencies were not different between diabetic patients with and without nephropathy (chi2 = 3, 386, p > 0.005; chi2 = 2.320, p > 0.005, respectively). 17354258 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The MTHFR genotype and allele frequencies were different between diabetic patients with and without nephropathy (chi2=12.27, P<0.005; chi2=8.77, P<0.005, respectively). 15126006 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. 11532106 2001
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The prevalence of polymorphism in the methylene-tetrahydro-folate-reductase (MTHFR) gene (677C-->T) was evaluated in diabetic pregnancy complicated by preeclampsia, nephropathy, retinopathy, and preterm delivery. 11531629 2001
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The MTHFR genotype and allele frequencies were not significantly different between patients with and without nephropathy. 10765003 2000
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.400 GeneticVariation group BEFREE The allele frequency of the C677T polymorphism in the MTHFR gene was 0.313 in the whole study population [wild-type (CC), 301; heterozygous (CT), 272; and homozygous mutant (TT), 63 patients, respectively] and showed no difference in the patient subgroups with various renal diseases. 10027946 1999