Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans. 24948143 2014
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 Biomarker group BEFREE Similarly, other genes such as Nephrin (NPHS1) and Podocin (NPHS2) contribute to the loss of renal function during renal diseases. 19520069 2009
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE The most common mutations are in 4 genes, 3 of which are podocyte genes: NPHS1 (Finnish nephropathy), NPHS2 (podocin-induced focal segmental glomerulosclerosis), WT1 (diffuse mesangial sclerosis), and LAMB2 (Pierson syndrome). 18462046 2008
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Mutations affecting a number of slit diaphragm proteins, including nephrin (encoded by NPHS1), lead to renal disease owing to disruption of the filtration barrier and rearrangement of the actin cytoskeleton, although the molecular basis for this is unclear. 16525419 2006
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 Biomarker group CTD_human IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. 16382022 2006
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Mutations or deregulation of NPHS1 are associated with a variety of renal diseases, including the Finnish type congenital nephrotic syndrome. 15579507 2004
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Variations in the nephrin gene may also affect the degree of proteinuria in acquired kidney diseases. 12631336 2003
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy. 12920248 2003
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 Biomarker group CTD_human mAb 5-1-6 nephropathy and nephrin. 12012391 2002
Entrez Id: 4868
Gene Symbol: NPHS1
NPHS1
0.380 GeneticVariation group BEFREE Congenital nephrotic syndrome of the Finnish type (CNF or NPHS1) is an autosomal recessive kidney disorder resulting in severe proteinurea and renal dysfunction. 11726550 2001