Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy. 31301369 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE To investigate its effect on renal disease, we intragastrically administrated DMAMCL, a dimethylamino Michael adduct of MCL for in vivo use, in two renal fibrosis models-the unilateral ureteral occlusion (UUO) model and an ischaemia-reperfusion injury (IRI) model and used MCL in combination with transforming growth factor beta 1 (TGF-β1) on mouse tubular epithelial cells (mTEC) in vitro. 30976056 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset. 31480595 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE We conclude that SGLT2i block basal and TGF-β1-induced expression of key mediators of renal fibrosis and kidney disease progression in two independent human PT cell lines. 30539648 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE Collectively, this study suggests that FHL2, via modulating β-catenin signalling, may implicate in regulation of TGF-β1-mediated tubular EMT and could be a potential therapeutic target for fibrotic kidney disease. 29193729 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE <b>Conclusion:</b> This study has advanced our current knowledge of mechanisms that contribute to the expression of TGF-β1-regulated genes involved in the pathogenesis of kidney disease. 30618784 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-β1 compared to control groups, which were partially attenuated by metformin treatment. 29380373 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE TGF-β1 downstream effectors were detected in vitro, as well as in 50 biopsies of different human kidney diseases to explore their in vivo correlation. 30383875 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE These findings indicate that DAG oils can significantly reduce BG levels and the deposition of AGEs in renal tissue, as well as regulate the levels of transforming growth factor-β1 and connective tissue growth factor, thus delaying the progression of nephropathy. 29434785 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Transforming growth factor-β1 (TGF-β1) is the central mediator of renal fibrosis and numerous studies have focused on inhibition of TGF-β1 and its downstream targets for treatment of kidney disease. 29518614 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE The present study confirmed that Akt and glycogen synthase kinase (GSK)-3β, as TGF-β1 downstream signaling factors, are involved in fibrotic processes caused by kidney disease, which, however, has been rarely reported in the kidney transplant field. 28565830 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE Consistent with in vitro results, expression of miR-155, TGF-β1, desmin and caspase-9 was increased and nephrin was decreased in glomerular tissues with nephropathy in vivo experiments. 28719898 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 GeneticVariation group BEFREE Diabetic retinopathy was associated with GG genotype and G allele in TGF-β1 codon 25C/G polymorphism (p = 0.004 and p = 0.018) and the nephropathy was associated the lower frequency of GG genotype in IL-10 -1082G/A polymorphism (p = 0.049). 26064986 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Our results indicate that TBX3 acts as an anti-apoptotic factor in MC in vitro and may be involved in the mechanism by which TGF-β1 induces glomerulosclerosis and tubular fibrosis during the progression of nephropathies. 25158279 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE TGF-β1 mediated renal fibrosis is a common pathology implicated in this form of kidney disease. 24113078 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE TGF-β1 binds receptor II (TβRII) to exert its biological activities but its functional importance in kidney diseases remains largely unclear. 22190171 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 GeneticVariation group BEFREE Transforming growth factor-β1-gene polymorphism in the development of kidney disease after liver transplantation. 22366990 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Furthermore, we also demonstrated that TGF-β1 acts by stimulating Smad3 to positively or negatively regulate microRNAs to exert its fibrotic role in kidney disease. 21927575 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE We investigated the renoprotective effects of valsartan according to polymorphisms of the renin-angiotensin system and transforming growth factor-b1 (TGFB1) genes in patients with chronic non-diabetic proteinuric nephropathies. 21303424 2011
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 GeneticVariation group BEFREE Significant correlation between association of polymorphism in codon 10 of transforming growth factor-beta1 T (29) C with type 1 diabetes and patients with nephropathy disorder. 20039825 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE The differential association between TGF-beta1 and renal disease risk factors in blacks and whites suggests an explanation for the excess burden of end-stage renal disease in the black population, but this requires validation in an independent cohort. 19279557 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE Here we applied transcriptional profiling of kidneys from transforming growth factor-beta1 transgenic (Tg) mice, characterized by heterogeneity of kidney disease progression, to identify 43 genes that discriminate kidneys by severity of glomerular apoptosis before the onset of tubulointerstitial fibrosis in 2-week-old animals. 19465643 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 AlteredExpression group BEFREE Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells. 19110334 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group BEFREE It is unknown, however, whether latent TGF-beta1 also has this effect in immunologically mediated forms of renal disease such as anti-GBM crescentic glomerulonephritis. 18216320 2008
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.400 Biomarker group CTD_human Transforming growth factor-beta1 is associated with kidney damage in patients with essential hypertension: renoprotective effect of ACE inhibitor and/or angiotensin II receptor blocker. 18390891 2008