Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group BEFREE The anti-aging gene klotho is closely related to kidney disease, and an increase in the level of the klotho protein inhibits the progression of various kidney diseases. 31273547 2019
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation group BEFREE Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (α-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ). 30551370 2019
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group BEFREE In addition, we discuss the delivery strategy for Klotho in CNI-induced nephropathy. 31772699 2019
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group BEFREE Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Diabetic Patients and Its Association with Early Nephropathy. 30718148 2018
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression group BEFREE Klotho knockout mice display accelerated aging, and in humans Klotho circulating levels decline with age, renal disease and diabetes. 28993191 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group BEFREE Thus, our study clarifies how rhein regulation of Klotho expression contributes to its renoprotection and brings new insights into Klotho-targeted strategy for the treatment of kidney diseases of various etiologies. 27692562 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group BEFREE To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. 28315683 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression group BEFREE Increased oxidative DNA damage, accumulation of cell cycle-arrested cells and decreased Klotho expression are assumed to be age-related factors that are reportedly linked to kidney disease. 25504369 2015
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker group CTD_human Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium. 23665422 2013
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression group BEFREE Through independent and combined effects on renal phosphorus and vitamin D metabolism, alterations in FGF23 and Klotho expression are essential for maintaining mineral homeostasis in kidney disease. 23611556 2013
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression group BEFREE Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy. 23945089 2013
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression group BEFREE The renal Klotho mRNA and Klotho protein expressions were significantly reduced in the DXR nephropathy group. 20606417 2010