Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE We also found that quercetin can strongly reduce the concentration of serum creatinine, BUN, IL-1β, IL-6, and TNF-α in cisplatin-induced AKI model. 31497913 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE We hypothesised that polymorphisms in 4 candidate genes, namely angiotensin-converting enzyme (ACE), apolipoprotein-E (ApoE), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α) are associated with AKI. 30973904 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Previous studies have been indicated that tumor necrosis factor receptor-associated factor 6 (TRAF6)-induced inflammation leads to acute kidney injury (AKI). 30392071 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Reperfusion after ischemia may cause injury through generation of reactive oxygen and nitrogen species, inflammatory responses by increased levels of tumor necrosis factor-α (TNF-α) and interleukins (IL), and apoptotic processes, and leads to acute kidney injury (AKI). 31217925 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Serum sFas, IL-6, TNF-α, and ferritin levels were higher in the AKI group. 23566289 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE There was an increase in kidney expression of pro-inflammatory cytokines CXCL1 and TNF-α, known mediators of cisplatin-induced AKI, in IL-33-deficient mice. 29070568 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Correction to: Assessment of tumor necrosis factor alpha polymorphism TNF-α<sub>-238</sub> (rs 361525) as a risk factor for development of acute kidney injury in critically ill patients. 30027474 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE RNAi targeting PKC-α inhibited TNF-α-induced IP<sub>3</sub>R1 overexpression and in turn improved compromised GFR in the development of acute kidney injury during FHF in rats. 29357415 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Assessment of tumor necrosis factor alpha polymorphism TNF-α<sub>-238</sub> (rs 361525) as a risk factor for development of acute kidney injury in critically ill patients. 29978383 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE In a univariate regression model, IL-6, IL-17, and TNF-<i>α</i> levels showed an association with AKI development after LDLT. 29805315 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE In a cisplatin-induced AKI mouse model, elevated plasma MIF correlated with increased serum creatinine and the severity of renal inflammation and tubular necrosis, whereas deletion of MIF protected the kidney from cisplatin-induced AKI by largely improving renal functional and histological injury, and suppressing renal inflammation including upregulation of cytokines such as interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), IL-6, inducible nitric oxide synthase (iNOS), MCP-1, IL-8, and infiltration of macrophages, neutrophils, and T cells. 30077612 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Tumor necrosis factor-α (TNFα) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. 29520166 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE Compared with IR-induced AKI alone, ADMSC treatment significantly decreased the number of apoptotic cells, the level of total urinary protein and serum creatinine, the expression of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β, IFN-γ, TNF-α, IFN-γ, and TGF-β), and the inflammation-associated proteins (HGF and SDF1), but increased the expression of the anti-inflammatory cytokine, IL-10, and the anti-apoptotic regulator, Bcl-2. 28688148 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE The progression of OPG levels paralleled the deterioration of kidney and endothelial functions from sepsis to sepsis-AKI, revealed as progressively increased levels of serum E-selectin (15.3%), endothelin-1 (ET-1) (19.6%), and decreased nitric oxide (NO) (29.7%), associated with elevations of TNF-α (25.5%) and TGF-β (18%). 28840836 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE In children ≥2 years, patients in the highest tertile of preoperative IL-8 and postoperative TNFα had 4.9-fold (95% CI: 1.8-13.2) and 3.3-fold (95% CI: 1.2-9.0) higher odds of AKI compared with those in the lowest tertile. 28821332 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression disease BEFREE The expression of tumor necrosis factor receptor (TNFR) 2 was increased in both kidney cell lines and experimented rat kidney tissues following acute kidney injury. 28821873 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple organ failure (whole blood ex vivo tumor necrosis factor response to endotoxin < 200 pg/mL), 2) thrombocytopenia-associated multiple organ failure (new onset thrombocytopenia with acute kidney injury and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity < 57%), and/or 3) sequential multiple organ failure with hepatobiliary dysfunction (respiratory distress followed by liver dysfunction with soluble Fas ligand > 200 pg/mL), to those without any of these phenotypes. 28410274 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Transfection of miR-107 ASO recovered the expression of DUSP7, suppressed the phosphorylation of ERK, and decreased the secretion of TNF-α in the CECs of septic AKI patients and in the peritubular endothelial cells of septic AKI mice. 28063928 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Principle conclusions: The low producer genotypes of both TNF-α (-308 G/A) and IL-10 (-1082 G/A) polymorphisms could be considered a risk factor for the development of AKI in critically ill patients with severe sepsis, thus management technique implemented for this category should be modulated rescuing this sector of patients from the grave deterioration to acute kidney injury. 27788614 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Fatal outcome from pulmonary hemorrhages was associated with low TNF-α, high IL-1β, and high iNOS expression, a pattern possibly expressed also in dogs with other forms of acute kidney injury. 26824356 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians. 24059882 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation disease BEFREE The TNFA rs1800629 gene polymorphism is associated with markers of kidney disease severity and distant organ dysfunction among patients with AKI. 23796916 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE In this study, the combination of low TNF-α plus low IL-10 producer phenotypes was an independent risk factor to AKI and/or death and RRT and/or death in critically ill patients. 23607333 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease CTD_human Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats. 18460982 2008